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Functional Modules in Gametogenesis

open access: yesFrontiers in Cell and Developmental Biology, 2022
Gametogenesis, the production of eggs and sperm, is a fundamental process in sexually reproducing animals. Following gametogenesis commitment and sexual fate decision, germ cells undergo several developmental processes to halve their genomic size and ...
Mariko Kikuchi, Minoru Tanaka
doaj   +3 more sources

Regulation of entry into gametogenesis [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2011
Gametogenesis is a fundamental aspect of sexual reproduction in eukaryotes. In the unicellular fungiSaccharomyces cerevisiae(budding yeast) andSchizosaccharomyces pombe(fission yeast), where this developmental programme has been extensively studied, entry into gametogenesis requires the convergence of multiple signals on the promoter of a master ...
Folkert J Van Werven, Angelika Amon
exaly   +3 more sources

The Rim15-Endosulfine-PP2ACdc55 Signalling Module Regulates Entry into Gametogenesis and Quiescence via Distinct Mechanisms in Budding Yeast

open access: yesPLoS Genetics, 2014
Quiescence and gametogenesis represent two distinct survival strategies in response to nutrient starvation in budding yeast. Precisely how environmental signals are sensed by yeast cells to trigger quiescence and gametogenesis is not fully understood.
Sourav Sarkar, Jonathan B A Millar
exaly   +2 more sources

Plasmodium falciparum PP1 phosphatase is a key regulator of malaria parasite transmission [PDF]

open access: yesmBio
For the successful transmission of malaria parasites from humans to mosquitoes, Plasmodium falciparum gametocytes must remain in the bloodstream long enough to be taken up by a mosquito. Once ingested, they are then activated into gametes to continue the
Ludivine Royer   +10 more
doaj   +2 more sources

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

open access: yesPLoS Biology, 2008
Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events ...
Quinton L Fivelman   +2 more
exaly   +3 more sources

Oxidative Stress Is Associated with Telomere Interaction Impairment and Chromatin Condensation Defects in Spermatozoa of Infertile Males

open access: yesAntioxidants, 2021
Telomere length can be influenced by reactive oxygen species (ROS) generated by lifestyle factors or environmental exposure. We sought to determine whether oxidative stress has an impact on sperm nuclear alterations, especially on chromatin organization ...
Benoit Berby   +9 more
doaj   +1 more source

Knockout Serum Replacement as a Substitute for Exosome Free Serum

open access: yesTranslational Research in Urology, 2021
Exosomes, extracellular vesicles secreted from cells, are carriers containing proteins, lipids, and nucleic acids. By adhering and releasing their contents to the recipient cells, exosomes play a major role in cellular communication.
Keykavos Gholami
doaj   +1 more source

Effects of the exercise-inducible myokine irisin on proliferation and malignant properties of ovarian cancer cells through the HIF-1 α signaling pathway

open access: yesScientific Reports, 2023
Exercise has been shown to be associated with reduced risk and improving outcomes of several types of cancers. Irisin -a novel exercise-related myokine- has been proposed to exert beneficial effects in metabolic disorders including cancer.
Marziyeh Alizadeh Zarei   +4 more
doaj   +1 more source

Gametogenesis in a dish [PDF]

open access: yesCell Research, 2012
Recent progress in the induced pluripotent stem cell (iPSC) field as well as the establishment of germline stem cell isolation and culture methodologies may provide an in vitro platform for the study of physiological and pathological human gamete development and open new avenues for cell replacement-based personalized treatment of infertility.
Ying, Gu   +2 more
openaire   +2 more sources

The magnetic cell separation method reveals protective effect of melatonin on human spermatozoa from peroxide-induced apoptosis

open access: yesMiddle East Fertility Society Journal, 2023
Background The selection of non-apoptotic sperm is related to successful fertilization. This study investigated the protective effects of melatonin and the role of the MACS (magnetically activated cell sorting) method to prevent oxidative damage in vitro
Hassan Hassani Bafrani   +3 more
doaj   +1 more source

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