Results 61 to 70 of about 14,639 (152)

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Association between Liver Enzymes with Metabolically Unhealthy Obese Phenotype

Lipids in Health and Disease, 2018
Background Obesity could be classified into two phenotypes: metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). This study investigated the ability of liver enzymes to identify obesity phenotype.
Junhui Xie, Shujun Zhang, Xuefeng Yu, Yan Yang, Zhelong Liu, Gang Yuan, Shuhong Hu   +6 more
doaj   +1 more source

Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Mark Wijnen, Evert F. S. van Velsen, J. Gert‐Jan Milhous, Esmee Oussoren, Bram C. J. van der Eerden, Margreet A. E. M. Wagenmakers   +5 more
wiley   +1 more source

Serum Gamma Glutamyltransferase: A Biomarker for Identifying Postprandial Hypertriglyceridemia

Diabetes, Metabolic Syndrome and Obesity
Kunjie Zheng,1– 3 Xiaolong Li,1– 3 Yihua Rong,2 Xuejing Wang,4 Liping Hou,2 Wei Gu,2 Xiaoyu Hou,3 Yunpeng Guan,5 Lifang Liu,6 Jianlin Geng,2 Guangyao Song1,3 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s ...
Zheng K, Li X, Rong Y, Wang X, Hou L, Gu W, Hou X, Guan Y, Liu L, Geng J, Song G   +10 more
doaj  

High admission levels of γ-glutamyltransferase predict poor myocardial perfusion after primary percutaneous intervention

Clinics, 2011
OBJECTIVE: This retrospective study aimed to investigate the relationship between admission levels of serum y-glutamyltransferase and poor myocardial perfusion after primary percutaneous coronary intervention in patients with acute myocardial infarction.
Uygar Cagdas Yuksel, Turgay Celik, Murat Celik, Baris Bugan, Atila Iyisoy, Halil Yaman   +5 more
doaj   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Usefulness of admission gamma-glutamyltransferase level for predicting new-onset heart failure in patients with acute coronary syndrome with left ventricular systolic dysfunction

Türk Kardiyoloji Derneği Arşivi, 2014
Objectives: Our aim was to determine whether there is a relationship between admission gamma-glutamyltransferase (GGT) and subsequent heart failure hospitalizations in patients with acute coronary syndrome.
Savaş Sarıkaya, Gulay Aydın, Hasan Yucel, Hakkı Kaya, Kutay Yıldrımlı, Ahmet Başaran, Ali Zorlu, Şafak Şahin, Lütfü Akyol, Musa Bulut   +9 more
doaj   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Liver‐related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver‐derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the hypothesis that serum conjugated ...
Motoh Iwasa, Akiko Eguchi, Motoyuki Kohjima, Teruo Miyazaki, Hiroshi Kitamura, Yuko Takami, Naoki Yamashita, Mina Tempaku, Kiyora Izuoka, Yoshinao Kobayashi, Yoshiyuki Takei, Akira Honda, Hayato Nakagawa, Tadashi Ikegami, Makoto Nakamuta, Jun Okabe, Aldo J. Montano‐Loza   +16 more
wiley   +1 more source

Clinical Exome Sequencing in Unexplained Hyperferritinemia Reveals Digenic and Oligogenic Inheritance Beyond Iron Homeostasis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Hyperferritinemia encompasses heterogeneous genetic etiologies beyond HFE‐related hemochromatosis. Current guidelines recommend testing for rare hemochromatosis genes, yet no consensus exists on comprehensive genomic approaches.
Paul Morel, Maël Silva Rodriguez, Cyriaque Benmouffek, Betul Goksen, Céline Chéry, Vincent Haghnejad, Mouni Bensenane, François Feillet, Jean‐Louis Guéant, Farès Namour, Jean‐Pierre Bronowicki, Abderrahim Oussalah   +11 more
wiley   +1 more source