Results 71 to 80 of about 14,639 (152)

Salivary gamma-glutamyltransferase activity as an indicator of redox homeostasis in breast cancer

Oncologie
One of the main participants in maintaining the redox balance is glutathione (GSH), the metabolism of which directly depends on the activity of gamma-glutamyltransferase (GGT), and the content of amino acids cysteine (Cys), methionine (Met), glutamine ...
Dyachenko Elena I., Sarf Elena A., Bel’skaya Lyudmila V.   +2 more
doaj   +1 more source

Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China

International Journal of Infectious Diseases, 2016
Objectives: About 2% of the world population is infected with hepatitis C virus (HCV), a leading cause of hepatic cirrhosis and hepatocellular carcinoma. The Niemann–Pick C1-like 1 cholesterol absorption receptor (NPC1L1) was recently identified to be an
A.-Mei Zhang, Cheng-Lin Zhang, Yuzhu Song, Ping Zhao, Yue Feng, Binghui Wang, Zheng Li, Li Liu, Xueshan Xia   +8 more
doaj   +1 more source

Effect of enzalutamide on anticoagulant therapy with edoxaban in patients with prostate cancer

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1117-1125, April 2026.
Aims Treatment with enzalutamide in prostate cancer is challenging due to its high potential for drug–drug interactions, particularly in the typically older population of patients with frequent comorbidities treated with multiple drugs, such as anticoagulants.
Catharina J. P. Op 't Hoog, Niven Mehra, Anouk van Kleef, Diederik M. Somford, Inge M. van Oort, Alex L. T. Imholz, Paul Hamberg, Nielka P. van Erp, Emmy Boerrigter   +8 more
wiley   +1 more source

Biliary Complication Under Nonoperative Management in High‐Grade Liver Injury: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT In children, nonoperative management (NOM) of (isolated) blunt solid organ injury is an established treatment method in hemodynamically stable patients. Although close monitoring and meticulous reevaluation are mandatory, complications may occur and may need diagnostic or therapeutic adjuncts.
Jonathan Lovis, Marco Schmitz, Remus Frei, Thomas Krebs, Frank‐Martin Häcker, Christoph Matissek   +5 more
wiley   +1 more source

Gamma-glutamyltransferases: exploring the complexity of a multi-functional family of enzymes.

Frontiers in Pharmacology, 2014
Maria eFranzini, Maria eFranzini, Alfonso ePompella, Alessandro eCorti   +3 more
doaj   +1 more source

The Clinical Manifestation of Homozygous Huntington's Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Huntington's disease is an incurable neurodegenerative disease with deficits in many areas including cognitive, psychiatric, and most notably, motor. It is autosomal dominant, meaning one affected allele is enough to express the condition.
Brishti Sengupta, Pritha Dasgupta
wiley   +1 more source

Phenotyping of Fontan‐Associated Renal Physiology and Disease

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
Gaston van Hassel, Jozine M. ter Maaten, Iris E. Beldhuis, Eryn T. Liem, Bastiaan Zwart, Stephan J. L. Bakker, Rolf M. F. Berger, Joost P. van Melle   +7 more
wiley   +1 more source

The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation

MedComm, Volume 7, Issue 4, April 2026.
Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata, Gumpei Yoshimatsu, Ryo Kawakami, Seiichi Tanaka, Shohta Kodama   +4 more
wiley   +1 more source

Maternal childhood adversity as an upstream vulnerability for prenatal alcohol use and maternal mental health

Alcohol, Clinical and Experimental Research, Volume 50, Issue 4, April 2026.
This study examined associations between maternal adverse childhood experiences (mACEs) and alcohol use in pregnancy, and evaluated the independent and joint effects of mACEs and alcohol on maternal mental health. High mACEs were nearly twice as common in the Alcohol group as in Controls, with physical abuse, household substance use, and family ...
Ludmila N. Bakhireva, Xingya Ma, Sonia Macias Rodriguez, Melissa H. Roberts   +3 more
wiley   +1 more source

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source