Results 31 to 40 of about 25,883 (316)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Naked Forward Shock Seen in the TeV Afterglow Data of GRB 221009A
The Astrophysical JournalWe explore the implications of the light curve of the early TeV gamma-ray afterglow of GRB 221009A reported by the LHAASO Collaboration. We show that the reported offset of the reference time, T _* , allows the determination of the activation time of the
Dmitry Khangulyan +2 more
doaj +1 more source
Gamma-Ray Bursts as Neutrino Sources [PDF]
, 2017 13 pages, review to appear in "Neutrino Astronomy- Current status, future prospects", Eds. T. Gaisser \& A. Karle (World Scientific)
openaire +3 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
The Astrophysical JournalGamma-ray bursts (GRBs) are particle acceleration sites that can emit photons in the very high-energy (VHE) domain through nonthermal processes. From 2004 until 2018, the current generation of Imaging Atmospheric Cherenkov Telescopes (IACTs) did not ...
H. Ashkar +5 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Gamma-Ray Bursts as Multienergy Neutrino Sources
Advances in Astronomy, 2015 We review theoretical models for nonelectromagnetic emission, mainly neutrinos and cosmic rays, from gamma-ray bursts (GRBs). In various stages of the relativistic jet propagation, cosmic-ray ion acceleration and subsequent neutrino emission are ...
Katsuaki Asano, Kohta Murase
doaj +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To generate high‐quality stereotactic radiosurgery (SRS) plans for single cranial lesions using 4Pi planning technique and compare these to our clinical “status quo” plans. Methods Eighteen vestibular schwannoma (VS) patients previously planned with Varian Eclipse RapidArc and treated on a Varian TrueBeam using 6FFF MV photon beams ...
Ganesh Narayanasamy +4 more
wiley +1 more source
Is Gamma-Ray Burst 221009A Really a Once-in-10,000 yr Event?
The Astrophysical JournalGamma-ray bursts (GRBs) brighter than the GRB 221009A, the brightest yet observed, have previously been estimated to occur at a rate of one per 10,000 yr, based on the extrapolation of the distribution of fluences of the long-GRB population. We show that
Justin D. Finke, Soebur Razzaque
doaj +1 more source
The Astrophysical Journal Letters, 2023 The detection of the hyper-bright gamma-ray burst (GRB) 221009A enables us to explore the nature of the GRB emission and the origin of very high-energy gamma rays.
B. Theodore Zhang +5 more
doaj +1 more source