Results 151 to 160 of about 1,241,760 (315)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Multi-institutional study of ‘Sandwich treatment’ for motor area large brain metastases (LBM) with diameter over 3 cm

Radiology and Oncology
The objective of the present study was to explore the effectiveness and safety of ‘Sandwich treatment’ strategy for large brain metastases (LBM) with diameter over 3 cm (minimum volume >= 15 cm3) located in motor area.
Wang Zheng, Chen Haining, Chen Qun, Zhu Yucun, Li Min, Zhou Jia   +5 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Bridging Imaging and Therapy: A Review of Advances in Neuroradiology and Neuro-Oncology

Clinical and Translational Neuroscience
Neuroradiology and neuro-oncology are rapidly emerging fields in the diagnosis and treatment of central nervous system (CNS) diseases, including brain tumors.
Venkatraman Pitchaikannu, Subramani Vellaiyan, Shweta Kedia, Vivek Tandon, Rajinder Kumar, Deepak Agarwal, Manoj Phalak, Satish Kumar Verma, Dattaraj P. Sawarkar, Kanwaljeet Garg, Gopishankar Natanasabapathi   +10 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Peligro por ciclones tropicales en la Zona Especial de Desarrollo del Mariel

Revista de Investigaciones Marinas
Las instalaciones industriales son vulnerables al impacto de los fenómenos naturales. La afectación a una instalación puede provocar grandes pérdidas económicas y desencadenar otros procesos que afecten la salud humana y generen contaminación ambiental.
Maria de los Angeles Zamora Fernández, Julia Azanza Ricardo, Kenia Hernández Valdés   +2 more
doaj  

Total gamma-gamma and gamma*-gamma* Cross Sections Measured at LEP

, 2001
Recent results on total cross-section measurements in gamma-gamma and gamma*-gamma* collisions at LEP are reported. Phenomenological fits to the data are presented.
openaire   +2 more sources

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Daftar Isi GAMMA Volume 4 Nomor 2, Maret 2009 [PDF]

, 2012
Volume 4 Nomor 2, Maret 2009ISSN : 0216 - 9037Ariasi Perendaman Pada Campuran Beton Aspal Terhadap Nilai Stabilitas MarshallAndi Saiful Amal 81 - 85Model Simulasi Untuk Penyelesaian Problem Integrasi Produksi-DistribusiAnnisa Kesy Gaside 86 - 94Disain ...
Isi, Daftar
core  

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source