Results 61 to 70 of about 2,375,747 (287)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Estimation and Compensation of the Ionospheric Path Delay Phase in PALSAR-3 and NISAR-L Interferograms

Atmosphere
Spatial and temporal variation in the free electron concentration in the ionosphere affects SAR interferograms, in particular at low radar frequencies.
Urs Wegmüller, Charles Werner, Othmar Frey, Christophe Magnard   +3 more
doaj   +1 more source

Greenland-wide inventory of ice marginal lakes using a multi-method approach

Scientific Reports, 2021
Ice marginal lakes are a dynamic component of terrestrial meltwater storage at the margin of the Greenland Ice Sheet. Despite their significance to the sea level budget, local flood hazards and bigeochemical fluxes, there is a lack of Greenland-wide ...
Penelope How, Alexandra Messerli, Eva Mätzler, Maurizio Santoro, Andreas Wiesmann, Rafael Caduff, Kirsty Langley, Mikkel Høegh Bojesen, Frank Paul, Andreas Kääb, Jonathan L. Carrivick   +10 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

How to take shortcuts in Euclidean space: making a given set into a short quasi-convex set

, 2012
For a given connected set $\Gamma$ in $d-$dimensional Euclidean space, we construct a connected set $\tilde\Gamma\supset \Gamma$ such that the two sets have comparable Hausdorff length, and the set $\tilde\Gamma$ has the property that it is quasiconvex ...
Azzam, Jonas, Schul, Raanan
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Assessment of Hongtu-1 Multi-Static X-Band SAR Constellation Interferometry

Remote Sensing
In 2023, the Chinese company PIESAT launched the multi-static X-band SAR constellation Hongtu-1 (HT1). HT1 consists of the active monostatic SAR sensor HT1-A and the three additional passive SAR receivers HT1-B, HT1-C and HT1-D.
Urs Wegmüller, Christophe Magnard, Othmar Frey   +2 more
doaj   +1 more source

Long-Term Survival in a Patient with Multiple Brain Metastases from Small-Cell Lung Cancer Treated with Gamma Knife Radiosurgery on Four Occasions: A Case Report

Case Reports in Neurological Medicine, 2012
Brain metastases are the most common cancerous neoplasm in the brain. The treatment of these lesions is challenging and often includes a multimodality management approach with whole-brain radiation therapy, stereotactic radiosurgery, and neurosurgery ...
Ameer L. Elaimy, Sudheer R. Thumma, Andrew F. Lamm, Alexander R. Mackay, Wayne T. Lamoreaux, Robert K. Fairbanks, John J. Demakas, Barton S. Cooke, Christopher M. Lee   +8 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Global seasonal Sentinel-1 interferometric coherence and backscatter data set

Scientific Data, 2022
Measurement(s) Seasonal C-band SAR coherence and backscatter from Dec. 2019 to Nov. 2020 Technology Type(s) SAR interferometric and radiometric terrain correction processing of Sentinel-1 SAR data Sample Characteristic - Environment Global land an ...
Josef Kellndorfer, Oliver Cartus, Marco Lavalle, Christophe Magnard, Pietro Milillo, Shadi Oveisgharan, Batu Osmanoglu, Paul A. Rosen, Urs Wegmüller   +8 more
doaj   +1 more source