Results 61 to 70 of about 1,403,017 (284)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cover Jurnal Gamma Vol.9, No.2, Maret 2014

, 2015
Cover Jurnal Gamma Vol.9, No.2, Maret ...
., Cover
core   +1 more source

Sensitivities on the anomalous quartic $$\gamma \gamma \gamma \gamma $$ and $$\gamma \gamma \gamma Z$$ couplings at the CLIC

The European Physical Journal C
AbstractIt is essential to directly investigate the self-couplings of gauge bosons in the Standard Model (SM) due to its non-Abelian nature, as these couplings play a significant role in comprehending the gauge structure of the model. The discrepancies between the Standard Model’s expectations and the measured value of gauge boson self-couplings serve ...
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cover Jurnal Gamma, Vol. 8, No.1, September 2012

, 2014
Cover Jurnal Gamma, Vol.
., Cover
core   +1 more source

Gamma Knife Radiosurgery Treatment for Metastatic Melanoma of the Trigeminal Nerve and Brainstem: A Case Report and a Review of the Literature

Case Reports in Neurological Medicine, 2013
Objective and Importance. Brainstem metastases (BSMs) are uncommon but serious complications of some cancers. They cause significant neurological deficit, and options for treatment are limited.
Halloran E. Peterson, Erik W. Larson, Robert K. Fairbanks, Wayne T. Lamoreaux, Alexander R. Mackay, Jason A. Call, John J. Demakas, Barton S. Cooke, Christopher M. Lee   +8 more
doaj   +1 more source

Implementing An Integrated Control Program To Control Powdery Mildew And Decreased Associated Plant Diseases Of Grapes In Egypt [PDF]

Journal of Productivity and Development
Powdery mildew, caused by  Uncinula necator L. fungus, is one of the most important plant diseases that affect the grape crop and leads to a huge loss in the crop.
Taha Maklad, Thauria Abo elwafa, Sahar Sharkawy, Mohamed Munir, Hesham Mohamed, Ismail Rashid, Salah Youssef   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Estimation and Compensation of the Ionospheric Path Delay Phase in PALSAR-3 and NISAR-L Interferograms

Atmosphere
Spatial and temporal variation in the free electron concentration in the ionosphere affects SAR interferograms, in particular at low radar frequencies.
Urs Wegmüller, Charles Werner, Othmar Frey, Christophe Magnard   +3 more
doaj   +1 more source