Results 31 to 40 of about 166,522 (267)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Some generalized inequalities involving extended beta and gamma functions for several variables

Journal of Inequalities and Applications
Recently, extensions of the gamma and beta functions have been studied due to their appealing properties and wide range of applications in various scientific fields. This note aims to investigate generalized inequalities associated with the extended beta
S. Mubeen, I. Aslam, Ghazi S. Khammash, Saralees Nadarajah, Ayman Shehata   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A New type of Connected Sets via Bioperations

International Journal of Analysis and Applications, 2018
The purpose of this paper is to introduce the notion of $\alpha_{(\gamma, \gamma^{'})}$-separated sets and study their properties in topological spaces, then we introduce the notions of $\alpha_{(\gamma, \gamma^{'})}$-connected and $\alpha_{(\gamma ...
Hariwan Z. Ibrahim
doaj   +2 more sources

Inequalities for Beta and Gamma functions via some classical and new integral inequalities

Journal of Inequalities and Applications, 2000
In this survey paper we present the natural applications of certain integral inequalities such as Chebychev's inequality for synchronous and asynchronous mappings, Hölder's inequality and Grüss' and Ostrowski's inequalities for the celebrated ...
Agarwal RP, Dragomir SS, Barnett NS
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Directional convexity and characterizations of Beta and Gamma functions

, 2015
The logarithmic convexity of restrictions of the Beta functions to rays parallel to the main diagonal and the functional equation \[ \left( x+1\right) =\frac{x\left( x+k\right) }{\left( 2x+k+1\right) \left( 2x+k\right) } \left( x\right) ,\ \ \ \ \ \ x>0, \] for $k>0$ allow to get a characterizations of the Beta function. This fact and a notion
Himmel, Martin, Matkowski, Janusz
openaire   +3 more sources