Results 61 to 70 of about 187,405 (281)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Monotonicity and Convexity Results for Functions Involving the Gamma Function [PDF]

, 2003
Qi, Feng, Chen, Chao-Ping
core   +6 more sources

Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae [PDF]

Memorias do Instituto Oswaldo Cruz, 2003
beta-glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and interferon-gamma (IFN-gamma ...
AC Pelizon, R Kaneno, AMVC Soares, DA Meira, A Sartori   +4 more
doaj  

Majorization problems for two subclasses of analytic functions connected with the Liu–Owa integral operator and exponential function

Journal of Inequalities and Applications, 2018
In the present paper, we investigate majorization properties for the class Mβα(p,γ) $M_{\beta}^{\alpha}(p,\gamma)$ of uniformly starlike functions and the class Nβα(p,θ) $N_{\beta}^{\alpha}(p,\theta)$ of spiral-like functions related to an exponential ...
Huo Tang, Guantie Deng
doaj   +1 more source

Directional convexity and characterizations of Beta and Gamma functions

, 2015
The logarithmic convexity of restrictions of the Beta functions to rays parallel to the main diagonal and the functional equation \[ ϕ\left( x+1\right) =\frac{x\left( x+k\right) }{\left( 2x+k+1\right) \left( 2x+k\right) }ϕ\left( x\right) ,\ \ \ \ \ \ x>0, \] for $k>0$ allow to get a characterizations of the Beta function.
Himmel, Martin, Matkowski, Janusz
openaire   +3 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

On $(\beta,\gamma)$-Chebyshev functions and points of the interval

, 2021
In this paper, we introduce the class of $(\beta,\gamma)$-Chebyshev functions and corresponding points, which can be seen as a family of {\it generalized} Chebyshev polynomials and points. For the $(\beta,\gamma)$-Chebyshev functions, we prove that they are orthogonal in certain subintervals of $[-1,1]$ with respect to a weighted arc-cosine measure. In
De Marchi, Stefano, Elefante, Giacomo, Marchetti, Francesco   +2 more
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source