Results 61 to 70 of about 442,522 (298)

A New type of Connected Sets via Bioperations

International Journal of Analysis and Applications, 2018
The purpose of this paper is to introduce the notion of $\alpha_{(\gamma, \gamma^{'})}$-separated sets and study their properties in topological spaces, then we introduce the notions of $\alpha_{(\gamma, \gamma^{'})}$-connected and $\alpha_{(\gamma ...
Hariwan Z. Ibrahim
doaj   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Directional convexity and characterizations of Beta and Gamma functions

, 2015
The logarithmic convexity of restrictions of the Beta functions to rays parallel to the main diagonal and the functional equation \[ \left( x+1\right) =\frac{x\left( x+k\right) }{\left( 2x+k+1\right) \left( 2x+k\right) } \left( x\right) ,\ \ \ \ \ \ x>0, \] for $k>0$ allow to get a characterizations of the Beta function. This fact and a notion
Himmel, Martin, Matkowski, Janusz
openaire   +3 more sources

Functional roles of DNA polymerases beta and gamma. [PDF]

Proceedings of the National Academy of Sciences, 1979
The physiological functions of DNA polymerases (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) beta and gamma were investigated by using neuronal nuclei and synaptosomes isolated from rat brain. UV irradiation of neuronal nuclei from 60-day-old rats resulted in a 7- to 10-fold stimulation of DNA repair synthesis attributable ...
U, Hübscher, C C, Kuenzle, S, Spadari
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Similarities in Populations of Star Clusters

, 2012
We compare the observed mass functions and age distributions of star clusters in six well-studied galaxies: the Milky Way, Magellanic Clouds, M83, M51, and Antennae.
Chandar, Rupali, Fall, S. Michael
core   +1 more source

Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.

Journal of Biological Chemistry, 1993
Recombinant expression of either the alpha or beta platelet-derived growth factor (PDGF) receptors in 32D hematopoietic cells allows efficient coupling of PDGF with mitogenic and chemotactic signaling pathways inherently expressed by those cells. PDGF-BB
M. Heidaran, J. Beeler, Jin-chen Yu, T. Ishibashi, William J. LaRochelle, J. Pierce, Stuart A. Aaronson   +6 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Some properties of the Generalized Jacobi polynomial

Researches in Mathematics
An attempt is made to find recurrence relation and further properties of the generalized Jacobi polynomial $P_{n,\tau }^{\left( {\alpha ,\gamma ,\beta } \right)}(x)$ .
D. Waghela, S.B. Rao
doaj   +1 more source