Results 41 to 50 of about 5,328,194 (289)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The Gamma Distribution [PDF]

open access: yesSignificance, 2019
AbstractJohn Dagpunar introduces a probability distribution to model real-valued positive measurements, such as time spent queuing for a taxi or waiting for a hospital ...
openaire   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Measurement Invariance, Entropy, and Probability

open access: yesEntropy, 2010
We show that the natural scaling of measurement for a particular problem defines the most likely probability distribution of observations taken from that measurement scale.
D. Eric Smith, Steven A. Frank
doaj   +1 more source

Effect of Probability Distribution of the Response Variable in Optimal Experimental Design with Applications in Medicine

open access: yesMathematics, 2021
In optimal experimental design theory it is usually assumed that the response variable follows a normal distribution with constant variance. However, some works assume other probability distributions based on additional information or practitioner’s ...
Sergio Pozuelo-Campos   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Approximating the Randomized Hitting Time Distribution of a Non-stationary Gamma Process [PDF]

open access: yes
The non-stationary gamma process is a non-decreasing stochastic process with independent increments. By this monotonic behavior this stochastic process serves as a natural candidate for modelling time-dependent phenomena such as degradation. In condition-
Nicolai, R.P., Frenk, J.B.G.
core   +2 more sources

Quantitative comparison of presumed-number-density and quadrature moment methods for the parameterisation of drop sedimentation

open access: yesMeteorologische Zeitschrift, 2014
In numerical weather prediction models, parameterisations are used as an alternative to spectral modelling. One type of parameterisations are the so-called methods of moments.
Corinna Ziemer   +4 more
doaj   +1 more source

Poly-Weighted Exponentiated Gamma Distribution with Application

open access: yesJournal of Statistical Theory and Applications (JSTA), 2020
This paper proposes a weighting of the exponentiated gamma distribution with a polynomial function called the poly-weighted exponentiated gamma distribution (PWEGD).
E. B. Nkemnole, E. M. Ikegwu
doaj   +1 more source

On estimation of high quantiles for certain classes of distributions [PDF]

open access: yesYugoslav Journal of Operations Research, 2015
We investigate the rate of convergence of the direct-simulation estimator ˆ xp(n) of a large quantile xp of the Pareto and Gamma distributions. The upper bound of the probability P{|xp(n)- xp|>ε is determined.
Stanojević Jelena
doaj   +1 more source

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