Results 41 to 50 of about 511,939 (260)

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Colostrum quality in Northern Italy: The role of dry cow nutrition and colostrum feeding management

Czech Journal of Animal Science
This study investigated the effects of dry cow feeding on colostrum quality. A survey was conducted, and samples of colostrum and feed ingredients were collected from 25 dairy farms in Northern Italy.
Martina Pavesi, Giulia Gislon, Serena Bonizzi, Stefania Colombini, Nicola Palladini, Maddalena Zucali   +5 more
doaj   +1 more source

Passive immunity transfer and serum constituents of crossbred calves

Pesquisa Veterinária Brasileira, 2012
Passive immunity transfer (PIT) evaluation is an essential tool for the maintenance of healthy calves during the first months of life. Since lactation number and breed have been proven to influence immunoglobulin levels in colostrum, the aim of this ...
Thaís G. Rocha, Ricardo P. Nociti, Alexandre A.M. Sampaio, José Jurandir Fagliari   +3 more
doaj   +1 more source

The pathogenetic aspects of acute intestinal infections of suckling piglets

BIO Web of Conferences, 2020
According to the studies piglets with intestinal infections compared to the clinically healthy animals, have lower the content of total protein, gamma globulins and general immunoglobulins, higher levels of malondialdehyde and endogenous intoxication ...
Shakhov Alexey G., Sashnina Larisa Yu., Vladimirova Julia Y., Jeines Maria Y., Samuilenko Anatoly Y.   +4 more
doaj   +1 more source

Small scale purification and biophysical characterization of haptoglobin derived from human Cohn fraction IV

Biotechnology Progress, EarlyView.
Abstract Haptoglobin (Hp) is a polymorphic acute phase α‐2 glycoprotein found in plasma that plays a critical role in binding, neutralizing, and removing cell‐free hemoglobin (Hb) from the circulation. Under clinical conditions characterized by high levels of hemolysis, such as in patients with sickle cell disease (SCD), large quantities of cell‐free ...
Shuwei Lu, Mohd Asim Khan, Pedro Cabrales, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +5 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

KETIDAKSAMAAN PADA FUNGSI Q-GAMMA

, 2012
Alsina and Tomas (2005) discuss about inequaty of the gamma function by geometricalapproach. Sandor (2005) and Baiduri (2008) discuss about some inequalities that involves the gammafunction based on the series representaion of psi function.
., Baiduri
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Certain Logarithmically N-Alternating Monotonic Functions Involving Gamma and q-Gamma Functions [PDF]

, 2005
In the paper, three basic properties of the logarithmically N-alternating monotonic functions are established and the monotonicity results of some functions involving the gamma and q-gamma functions, which are obtained in [W. E. Clark and M. E.
Qi, Feng
core   +5 more sources