Results 61 to 70 of about 4,361,784 (275)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

The Refractive Index of Silicon at Gamma Ray Energies

open access: yes, 2011
4 pages, 3 ...
Habs, D.   +3 more
openaire   +2 more sources

Testicular gamma glutamyl-transpeptidase: an index of Sertoli cell function in man [PDF]

open access: yesReproduction, 1976
Many workers have studied testicular enzymes as specific markers of spermatogenesis (Bishop, 1968). However, the enzymes evaluated have primarily reflected the presence or absence of germ cells per se and have added little to our understanding of maturational events that was not already available by histological examination.
R J, Sherins, G D, Hodgen
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Cover Jurnal Gamma Vol.9, No.2, Maret 2014

open access: yes, 2015
Cover Jurnal Gamma Vol.9, No.2, Maret ...
., Cover
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Distance from fractional Brownian motion with associated Hurst index 0<H<1/2 to the subspaces of Gaussian martingales involving power integrands with an arbitrary positive exponent

open access: yesModern Stochastics: Theory and Applications, 2020
We find the best approximation of the fractional Brownian motion with the Hurst index $H\in (0,1/2)$ by Gaussian martingales of the form ${\textstyle\int _{0}^{t}}{s^{\gamma }}d{W_{s}}$, where W is a Wiener process, $\gamma >0$.
Oksana Banna   +2 more
doaj   +1 more source

Influence of magnetic field and temperature on negative refractive index in a degenerate three-level atomic system

open access: yesCommunications in Physics
This work investigates the manipulation of the negative refractive index in a degenerate three-level \( \Lambda \)-type atomic system in the presence of an external magnetic field and Doppler broadening.
Bang Nguyen Huy   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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