Results 91 to 100 of about 170,362 (288)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A mobile antineutrino detector with plastic scintillators

, 2012
We propose a new type segmented antineutrino detector made of plastic scintillators for the nuclear safeguard application. A small prototype was built and tested to measure background events. A satisfactory unmanned field operation of the detector system
Agostinelli, Bernstein, Bernstein, Bowden, C. Ito, Furuta, Huber, Klimov, M. Minowa, Mueller, R. Nakata, S. Oguri, Vogel, Vogel, Y. Inoue, Y. Kato, Y. Kuroda   +16 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Machine learning-based ensemble prediction model for the gamma passing rate of VMAT-SBRT plan

Physica Medica
The purpose of this study was to accurately predict or classify the beam GPR with an ensemble model by using machine learning for SBRT(VMAT) plans.A total of 128 SBRT VMAT plans with 330 arc beams were retrospectively selected, and 216 radiomics and 34 plan complexity features were calculated for each arc beam.
Wenzhao Sun, Zijie Mo, Yongbao Li, Jifeng Xiao, Lecheng Jia, Sijuan Huang, Can Liao, Jinlong Du, Shumeng He, Li Chen, Wei Zhang, Xin Yang   +11 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Evaluation of Using an Octavius 4D Measuring System for Patient-Specific VMAT Quality Assurance

Radiation
Background: Quality assurance (QA) programs are designed to improve the quality and safety of radiation treatments, including patient-specific QA (PSQA).
Yawo Atsu Constantino Fiagan, Kodjo Joël Fabrice N‘Guessan, Adama Diakité, Komlanvi Victor Adjenou, Thierry Gevaert, Dirk Verellen   +5 more
doaj   +1 more source

Oblique electromagnetic instabilities for an ultra relativistic electron beam passing through a plasma

, 2006
We present an investigation of the electromagnetic instabilities which are trig gered when an ultra relativistic electron beam passes through a plasma.
A Bret, Fainberg Ya. B.
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

A feasibility study of deep learning prediction model for VMAT patient-specific QA

Frontiers in Oncology
PurposeThis study introduces a deep learning (DL) model that leverages doses calculated from both a treatment planning system (TPS) and independent dose verification software using Monte Carlo (MC) simulations, aiming to predict the gamma passing rate ...
Junjie Miao, Yuan Xu, Kuo Men, Jianrong Dai   +3 more
doaj   +1 more source