Results 61 to 70 of about 170,362 (288)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Automatic 3D Monte-Carlo-based secondary dose calculation for online verification of 1.5 T magnetic resonance imaging guided radiotherapy

Physics and Imaging in Radiation Oncology, 2021
Background and purpose: Hybrid magnetic resonance linear accelerator (MR-Linac) systems represent a novel technology for online adaptive radiotherapy.
Marcel Nachbar, David Mönnich, Oliver Dohm, Melissa Friedlein, Daniel Zips, Daniela Thorwarth   +5 more
doaj   +1 more source

Apollo-Soyuz pamphlet no. 2: X-rays, gamma-rays [PDF]

, 1977
The nature of high energy radiation and its penetration through earth's atmosphere is examined with emphasis on X-rays, gamma rays, and cosmic radiation and the instruments used in their detection.
From, T. P., Page, L. W.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Evidence of TeV gamma-ray emission from the nearby starburst galaxy NGC 253

, 2003
TeV gamma-rays were recently detected from the nearby normal spiral galaxy NGC 253 (Itoh et al., 2002). Observations to detect the Cherenkov light images initiated by gamma-rays from the direction of NGC 253 were carried out in 2000 and 2001 over a total
A. Asahara, A. Kawachi, A. Watanabe, Aharonian, Antonucci, Baum, Bhattacharya, C. Itoh, Carilli, Carraminana, D. L. Swaby, D. Nishida, de Vaucouleurs, Enomoto, Enomoto, Enomoto, F. Kajino, F. Tokanai, Fegan, G. V. Bicknell, Goldshmidt, H. Katagiri, H. Kubo, H. Moro, H. Muraishi, H. Tsunoo, Hara, Hillas, Hummel, Itoh, Itoh, J. Kushida, J. R. Patterson, K. Nishijima, K. Okumura, K. Sakurazawa, K. Tsuchiya, Kawachi, Kifune, Kubo, M. Mori, M. Ohishi, Mattila, Mohanty, Muraishi, Okumura, P. G. Edwards, R. Enomoto, R. J. Protheroe, R. W. Clay, S. Gunji, S. Hara, S. Kabuki, S. Watanabe, S. Yanagita, Sei. Hayashi, , Shin. Hayashi, , Sreekumar, Sreekumar, T. Hara, T. Hattori, T. Kifune, T. Naito, T. Nakase, T. Tanimori, T. Uchida, T. Yoshida, T. Yoshikoshi, Tanimori, Tanimori, van Buren, Voelk, Voelk, Y. Matsubara, Y. Mizumoto, Y. Muraki   +75 more
core   +1 more source

The Inverse G-Wishart Distribution and Variational Message Passing [PDF]

, 2020
Message passing on a factor graph is a powerful paradigm for the coding of approximate inference algorithms for arbitrarily graphical large models. The notion of a factor graph fragment allows for compartmentalization of algebra and computer code.
Maestrini, L., Wand, M. P.
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Exploiting the time of arrival of Cherenkov photons at the 28 m H.E.S.S. telescope for background rejection: Methods and performance

, 2015
In 2012, the High Energy Stereoscopic System (H.E.S.S.) was expanded by a fifth telescope (CT5). With an effective mirror diameter of 28m, CT5 is able to detect the Cherenkov light of very faint gamma-ray air showers, thereby significantly lowering the ...
Chalmé-Calvet, Raphaël, de Naurois, Mathieu, Holler, Markus, Tavernet, Jean-Paul   +3 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source