Results 81 to 90 of about 170,362 (288)

Observations of the supernova remnant W28 at TeV energies [PDF]

, 2000
The atmospheric Cerenkov imaging technique has been used to search for point-like and diffuse TeV gamma-ray emission from the southern supernova remnant, W28, and surrounding region. The search, made with the CANGAROO 3.8m telescope, encompasses a number
Dazeley, S. A., Edwards, P. G., Gunji, S., Hara, T., Holder, J., Kawachi, A., Kifune, T., Matsubara, Y., Mizumoto, Y., Mori, M., Muraishi, H., Muraki, Y., Naito, T., Nishijima, K., Ogio, S., Patterson, J. R., Roberts, M. D., Rowell, G. P., Sako, T., Sakurazawa, K., Susukita, R., Tamura, T., Tanimori, T., Thornton, G. J., Yanagita, S., Yoshida, T., Yoshikoshi, T.   +26 more
core   +1 more source

No observational constraints from hypothetical collisions of hypothetical dark halo primordial black holes with galactic objects

, 2009
It was suggested by several authors that hypothetical primordial black holes (PBHs) may contribute to the dark matter in our Galaxy. There are strong constraints based on the Hawking evaporation that practically exclude PBHs with masses m~1e15-1e16g and ...
Alcock, Antonella Garzilli, Barrau, Binney, Carr, Donea, Fredrik Johansson, Hawking, Julia K. Becker, Khlopov, Komatsu, Landau, Lei Qian, Marek A. Abramowicz, Meegan, Ostriker, Parks, Peter L. Biermann, Ricotti, Roncadelli, Sreekumar, Vandenbroucke, Xue, Yoo, Zhilyaev, Zwicky   +25 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Interpretations of galactic center gamma-ray excess confronting the PandaX-II constraints on dark matter-neutron spin-dependent scatterings in the NMSSM

, 2018
The Weakly Interacting Massive Particle (WIMP) has been one of the most attractive candidates for Dark Matter (DM), and the lightest neutralino ($\widetilde{\chi}^0_1$) in the Next-to-Minimal Supersymmetric Standard Model (NMSSM) is an interesting ...
He, Yangle, Lian, Jingwei, Pan, Yusi, Shang, Liangliang   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Research on Position Verification of Multi-Leaf Collimator (MLC) and Dose Verification Based on Electronic Portal Imaging Device

Zhongguo yiliao qixie zazhi
ObjectiveA quality control (QC) system based on the electronic portal imaging device (EPID) system was used to realize the Multi-Leaf Collimator (MLC) position verification and dose verification functions on Primus and VenusX accelerators.
Jianfeng SUI, Jiawei SUN, Kai XIE, Liugang GAO, Tao LIN, Xinye NI   +5 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

An Untriggered Search for Optical Bursts

, 2002
We present an untriggered search for optical bursts with the ROTSE-I telephoto array. Observations were taken which monitor an effective 256 square degree field continuously over 125 hours to m_{ROTSE}=15.7.
Brian Lee, Carl Akerlof, Don Casperson, Donald Smith, Eli Rykoff, Galen Gisler, Hog E., Jeff Bloch, Jim Wren, Richard Balsano, Robert Kehoe, Sandra Fletcher, Skiff B. A., Stuart Marshall, Timothy McKay, Tom Vestrand   +15 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application

Frontiers in Oncology, 2020
PurposeTo develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT ...
Chunhao Wang, Chenyang Liu, Yushi Chang, Kyle Lafata, Yunfeng Cui, Jiahan Zhang, Yang Sheng, Yvonne Mowery, David Brizel, Fang-Fang Yin, Fang-Fang Yin   +10 more
doaj   +1 more source