Results 201 to 210 of about 2,088,565 (252)

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

open access: yesAdvanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu   +14 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

open access: yesAdvanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao   +12 more
wiley   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

open access: yesAdvanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li   +13 more
wiley   +1 more source

Dual‐Functional Terahertz Manipulation of EuBa2Cu3O7 Superconductors via Cooper Pair Dynamics

open access: yesAdvanced Science, EarlyView.
We use a spintronic‐metasurface THz emitter to realize chiral THz generation. Using polarization‐tunable THz pulses, we investigate equilibrium and photoinduced THz responses in a 43 nm thick EuBa2Cu3O7 (EBCO) thin film. The EBCO film achieves 46.81 dB EMI shielding and 113% photoinduced THz modulation with 19.0 ps recovery, enabled by Cooper‐pair ...
Zhangshun Li   +10 more
wiley   +1 more source

Gamma radiation-induced mutation breeding for enhanced yield and stress tolerance in grapevine (Vitis vinifera L.). [PDF]

open access: yesBMC Plant Biol
Ud-Din N   +9 more
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang   +11 more
wiley   +1 more source

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