Results 61 to 70 of about 291,201 (341)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Fermi-LAT kills dark matter interpretations of AMS-02 data. Or not? [PDF]

, 2017
A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as
Belotsky, Konstantin, Budaev, Ruslan, Kirillov, Alexander, Laletin, Maxim   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Development of an advanced Compton camera with gaseous TPC and scintillator

, 2004
A prototype of the MeV gamma-ray imaging camera based on the full reconstruction of the Compton process has been developed. This camera consists of a micro-TPC that is a gaseous Time Projection Chamber (TPC) and scintillation cameras.
A. Tada, A. Takada, H. Kubo, H. Nishimura, H. Sekiya, K. Hattori, K. Miuchi, Kubo, Kurfess, Miuchi, Nagayoshi, Ochi, Orito, R. Orito, Schönfelder, T. Nagayoshi, T. Tanimori, Tanimori, Y. Okada   +18 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Identification of Gamma Spectrum Decayed by 238Pu as a Low Energy Photon Source

Journal of Isotopes, 2017
The gamma spectrum of 238Pu low energy photon source which was used for X-ray fluorescence analysis was analyzed by using P-type coaxial HPGe detector.
XU Xu;LIU Jia-qiang;LU Jing-bin;LIU Yu-min;MA Ke-yan;YANG Dong;LIU Yun-zuo
doaj   +1 more source

Gamma ray effects on flash memory cell arrays [PDF]

Nuclear Technology and Radiation Protection, 2012
Information stored in flash memories is physically represented by the absence or presence of charge on electrically isolated floating gates. Interaction of gamma rays with the insulators surrounding the floating gate produces effects that degrade the ...
Dolićanin Edin Ć.
doaj   +1 more source

How to use molecular clouds to study the propagation of cosmic rays in the Galaxy

, 2010
Observations of molecular clouds in the gamma ray domain provide us with a tool to study the distribution of cosmic rays in the Galaxy. This is because cosmic rays can penetrate molecular clouds, undergo hadronic interactions in the dense gas, and ...
Gabici, Stefano
core   +3 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source