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Gammaretrovirus Infections in Humans in the Past, Present, and Future: Have We Defeated the Pathogen? [PDF]
PathogensGammaretroviruses are ubiquitous pathogens, often associated with the induction of neoplasia, especially leukemia, lymphoma, and sarcoma, and with a propensity to target the germline.
Antoinette Cornelia van der Kuyl
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Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract [PDF]
Emerging Infectious Diseases, 2010 Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR.
Nicole Fischer +6 more
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PLoS Genetics, 2023 Despite the absence of a confirmed exogenously replicating retrovirus in Canis lupus familiaris (C. familiaris), past retroviral infections are evident in the genomes of living animals via the presence of endogenous retroviruses (ERVs).
Abigail S Jarosz +7 more
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PLoS Pathogens, 2006 Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer.
Anatoly Urisman +11 more
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Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV. [PDF]
PLoS ONE, 2010 BackgroundThe human exogenous gammaretrovirus XMRV is thought to be implicated in prostate cancer and chronic fatigue syndrome. Besides pressing epidemiologic questions, the elucidation of the tissue and cell tropism of the virus, as well as its ...
Kristin Stieler, Nicole Fischer
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Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species. [PDF]
PLoS ONE, 2012 Increasing evidence has indicated natural transspecies transmission of gammaretroviruses; however, viral-host interactions after initial xeno-exposure remain poorly understood. Potential association of xenotropic murine leukemia virus-related virus (XMRV)
Toshie Sakuma +6 more
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Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo [PDF]
Journal of Clinical Investigation, 2007 We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those with sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up to 5 years after treatment.
Kerstin Schwarzwaelder +53 more
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Unique Structure and Distinctive Properties of the Ancient and Ubiquitous Gamma-Type Envelope Glycoprotein [PDF]
Viruses, 2023 After the onset of the AIDS pandemic, HIV-1 (genus Lentivirus) became the predominant model for studying retrovirus Env glycoproteins and their role in entry.
Victoria Hogan, Welkin E. Johnson
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piRNA Defense Against Endogenous Retroviruses [PDF]
VirusesInfection by retroviruses and the mobilization of transposable elements cause DNA damage that can be catastrophic for a cell. If the cell survives, the mutations generated by retrotransposition may confer a selective advantage, although, more commonly ...
Milky Abajorga +2 more
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Biochemical characterization of novel retroviral integrase proteins. [PDF]
PLoS ONE, 2013 Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Allison Ballandras-Colas +4 more
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