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Vaccination studies with the mper of HIV-1 gp41 grafted into transmembrane protein of a gammaretrovirus [PDF]
, 2013 A vaccine against HIV-1 to keep the pandemic in bay is one of the major goals in vaccine development. Although the scientific field of vaccine development is largely supported with extensive fundings, attempts to design a vaccine to induce potent protection only remained successful in the macaque model, but not in human trials. In order to address this
N. Strasz
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The Prostate, 2011
AbstractBACKGROUNDThe occurrence of the retrovirus xenotropic murine leukemia virus (MLV)‐related virus (XMRV) has been reported in prostate tissue of patients with prostate cancer (PrCa). Considering the potential great medical and social relevance of this discovery, we investigated whether this finding could be confirmed in an independent group of ...
G. Verhaegh +5 more
semanticscholar +5 more sources
AbstractBACKGROUNDThe occurrence of the retrovirus xenotropic murine leukemia virus (MLV)‐related virus (XMRV) has been reported in prostate tissue of patients with prostate cancer (PrCa). Considering the potential great medical and social relevance of this discovery, we investigated whether this finding could be confirmed in an independent group of ...
G. Verhaegh +5 more
semanticscholar +5 more sources
Blood, 2008 Abstract Using gene therapy to protect hematopoietic stem cells (HSC) from alkylating agents used in the treatment of malignant disease is an attractive strategy to alleviate prolonged neutropenia and thrombocytopenia that is dose-limiting. Both adult and pediatric patients with glioblastomas urgently need improved therapeutic strategies
Brian C. Beard +3 more
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Partial correction of murine β-thalassemia with a gammaretrovirus vector for human γ-globin
Blood Cells, Molecules, and Diseases, 2006Several studies have demonstrated that recombinant lentivirus vectors containing extended globin gene expression cassettes and regulatory elements can ameliorate the pathogenic sequela in murine models of beta-thalassemia and sickle cell disease. Similarly promising results have not yet been obtained with recombinant gammaretrovirus vectors.
Tamon Nishino +2 more
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The Evolution of Gammaretrovirus Restriction Factors in the Mouse
2010Mice exposed to infectious retroviruses are subject to virus-induced disease or virus-induced genetic mutations. While mice are protected by the innate and acquired immune systems, they have also evolved numerous constitutively expressed antiviral factors that target various stages of the retroviral life cycle, and these factors have been identified ...
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Human Gene Therapy, 2006 The successful transduction and engraftment of human mobilized peripheral blood (MBP) CD34(+) cells are determined to a large extent by the ex vivo cell-processing conditions. In preparation for upcoming clinical trials, we investigated essential culture parameters and devised a short and efficient gammaretroviral transduction protocol entailing ...
Tülin Budak-Alpdoǧan +5 more
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Human Gene Therapy, 2007
Recent advances have allowed for improved retrovirus-mediated gene transfer, and therapeutic benefits have been described in patients. These successes have shown the potential of hematopoietic stem cell (HSC) gene therapy, but treatment-related leukemia ...
B. Beard +7 more
semanticscholar +1 more source
Recent advances have allowed for improved retrovirus-mediated gene transfer, and therapeutic benefits have been described in patients. These successes have shown the potential of hematopoietic stem cell (HSC) gene therapy, but treatment-related leukemia ...
B. Beard +7 more
semanticscholar +1 more source