Results 21 to 30 of about 4,044 (208)
Virology, 2016 Xenotropic/polytropic mouse leukemia viruses (X/P-MLVs) use the XPR1 gammaretrovirus receptor for entry. X/P-MLV host range is defined by usage of naturally occurring restrictive XPR1 receptors, and is governed by polymorphisms in the virus envelope glycoprotein and in XPR1.
Qingping Liu +2 more
semanticscholar +5 more sources
In Vitro Assembly of Virus-Like Particles of a Gammaretrovirus, the Murine Leukemia Virus XMRV [PDF]
Journal of Virology, 2011 ABSTRACT Immature retroviral particles are assembled by self-association of the structural polyprotein precursor Gag. During maturation the Gag polyprotein is proteolytically cleaved, yielding mature structural proteins, matrix (MA), capsid (CA), and nucleocapsid (NC), that reassemble into a mature viral particle.
Romana Hadravová +8 more
semanticscholar +5 more sources
Crystal Structures of Beta- and Gammaretrovirus Fusion Proteins Reveal a Role for Electrostatic Stapling in Viral Entry [PDF]
Journal of Virology, 2013 ABSTRACT Membrane fusion is a key step in the life cycle of all envelope viruses, but this process is energetically unfavorable; the transmembrane fusion subunit (TM) of the virion-attached glycoprotein actively catalyzes the membrane merger process. Retroviral glycoproteins are the prototypical system to study pH-independent viral entry.
Halil Aydin +2 more
semanticscholar +5 more sources
Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity [PDF]
Advances in Virology, 2011 Gammaretroviruses of several different host range subgroups have been isolated from laboratory mice. The ecotropic viruses infect mouse cells and rely on the host CAT-1 receptor.
Christine A. Kozak
semanticscholar +5 more sources
Molecular Characterization of a Novel Gammaretrovirus in Killer Whales ( Orcinus orca ) [PDF]
Journal of Virology, 2009 ABSTRACT There are currently no published data documenting the presence of retroviruses in cetaceans, though the occurrences of cancers and immunodeficiency states suggest the potential. We examined tissues from adult killer whales and detected a novel gammaretrovirus by degenerate PCR. Reverse transcription-PCR also demonstrated
Sarah LaMere +5 more
semanticscholar +4 more sources
Matrix Fibronectin Binds Gammaretrovirus and Assists in Entry: New Light on Viral Infections [PDF]
Journal of Virology, 2007 ABSTRACT A major entry route for the gammaretrovirus amphotropic murine leukemia virus (A-MLV) into NIH 3T3 fibroblasts is via caveola-dependent endocytosis. However, during the infection time, few viral particles can be observed intracellularly.
Christiane Beer, Lene Pedersen
semanticscholar +6 more sources
Ancient invasion of an extinct gammaretrovirus in cetaceans.
Virology, 2013 Endogenous gammaretroviruses (EGVs) have been widely studied in terrestrial mammals but seldom so in marine species. A genomic mining of the bottlenose dolphin (Tursiops truncatus) genome revealed a new EGV, termed Tursiops truncatus endogenous retrovirus (TTEV), which is divergent from extant mammalian EGVs.
Lina Wang +5 more
semanticscholar +3 more sources
Next-Generation Sequencing of Prostate Tumors Provides Independent Evidence of Xenotropic Murine Leukemia Virus-Related Gammaretrovirus Contamination [PDF]
Journal of Clinical Microbiology, 2011 In 2006, xenotropic murine leukemia virus (MLV)-related gammaretrovirus (XMRV) was isolated from prostate cancer tissue ([9][1]). However, subsequent studies have yielded conflicting and controversial results, with widespread detection of XMRV suggested to be the result of contamination with ...
Fan Mo +7 more
semanticscholar +4 more sources
Virology, 2015 Endogenous retroviruses (ERVs) were acquired during evolution of their host organisms after infection and mendelian inheritance in the germline by their exogenous counterparts. The ERVs can spread in the host genome and in some cases they affect the host phenotype. The cervid endogenous gammaretrovirus (CrERV) is one of only a few well-defined examples
H. Fábryová +4 more
semanticscholar +4 more sources
Infection, Viral Dissemination, and Antibody Responses of Rhesus Macaques Exposed to the Human Gammaretrovirus XMRV [PDF]
Journal of Virology, 2011 ABSTRACT Xenotropic murine leukemia-related virus (XMRV) was identified in association with human prostate cancer and chronic fatigue syndrome. To examine the infection potential, kinetics, and tissue distribution of XMRV in an animal model, we inoculated five macaques with XMRV intravenously.
Nattawat Onlamoon +15 more
semanticscholar +5 more sources