Results 21 to 30 of about 2,385 (164)

Polymorphic Integrations of an Endogenous Gammaretrovirus in the Mule Deer Genome [PDF]

Journal of Virology, 2011
ABSTRACT Endogenous retroviruses constitute a significant genomic fraction in all mammalian species. Typically they are evolutionarily old and fixed in the host species population. Here we report on a novel endogenous gammaretrovirus (CrERVγ; for cervid endogenous gammaretrovirus) in the mule deer ( Odocoileus ...
D. Elleder, Oekyung Kim, A. Padhi, Jason G Bankert, I. Simeonov, S. Schuster, N. Wittekindt, Susanne Motameny, M. Poss   +8 more
semanticscholar   +5 more sources

Endogenous Gammaretrovirus Acquisition in Mus musculus Subspecies Carrying Functional Variants of the XPR1 Virus Receptor [PDF]

Journal of Virology, 2013
ABSTRACT The xenotropic and polytropic mouse leukemia viruses (X-MLVs and P-MLVs, respectively) have different host ranges but use the same functionally polymorphic receptor, XPR1, for entry. Endogenous retroviruses (ERVs) of these 2 gammaretrovirus subtypes are largely segregated in different house mouse subspecies, but both MLV
Devinka Bamunusinghe, Qingping Liu, Xiaoyu Lu, Andrew J. Oler, C. Kozak   +4 more
semanticscholar   +5 more sources

Permissive XPR1 gammaretrovirus receptors in four mammalian species are functionally distinct in interference tests.

Virology, 2016
Xenotropic/polytropic mouse leukemia viruses (X/P-MLVs) use the XPR1 gammaretrovirus receptor for entry. X/P-MLV host range is defined by usage of naturally occurring restrictive XPR1 receptors, and is governed by polymorphisms in the virus envelope glycoprotein and in XPR1.
Qingping Liu, Yuhe Yan, C. Kozak
semanticscholar   +4 more sources

A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection. [PDF]

Cell Host & Microbe, 2009
Primate lentiviruses, including HIV-1, transduce terminally differentiated, nondividing myeloid cells; however, these cells are refractory to infection by gammaretroviruses such as murine leukemia virus (MLV). Here, we present evidence that a cellular restriction is the obstacle to transduction of macrophages by MLV.
Rajnish Kaushik, Xiaonan Zhu, R. Stranska, Yuanfei Wu, M. Stevenson   +4 more
semanticscholar   +6 more sources

Infection, Viral Dissemination, and Antibody Responses of Rhesus Macaques Exposed to the Human Gammaretrovirus XMRV [PDF]

Journal of Virology, 2011
ABSTRACT Xenotropic murine leukemia-related virus (XMRV) was identified in association with human prostate cancer and chronic fatigue syndrome. To examine the infection potential, kinetics, and tissue distribution of XMRV in an animal model, we inoculated five macaques with XMRV intravenously.
N. Onlamoon, J. Das Gupta, Prachi Sharma, Kenneth A. Rogers, S. Suppiah, Jeanne M. Rhea, R. Molinaro, Christina Gaughan, B. Dong, E. Klein, X. Qiu, S. Devare, G. Schochetman, J. Hackett, R. Silverman, F. Villinger   +15 more
semanticscholar   +5 more sources

In Vitro Assembly of Virus-Like Particles of a Gammaretrovirus, the Murine Leukemia Virus XMRV [PDF]

Journal of Virology, 2011
ABSTRACT Immature retroviral particles are assembled by self-association of the structural polyprotein precursor Gag. During maturation the Gag polyprotein is proteolytically cleaved, yielding mature structural proteins, matrix (MA), capsid (CA), and nucleocapsid (NC), that reassemble into a mature viral particle.
R. Hadravová, A. de Marco, P. Ulbrich, J. Štokrová, M. Doležal, I. Pichová, T. Ruml, J. Briggs, M. Rumlová   +8 more
semanticscholar   +4 more sources

The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice [PDF]

Journal of Virology, 2013
ABSTRACT Xenotropic mouse leukemia viruses (X-MLVs) are broadly infectious for mammals except most of the classical strains of laboratory mice. These gammaretroviruses rely on the XPR1 receptor for entry, and the unique resistance of laboratory mice is due to two mutations in different putative XPR1 extracellular loops.
Carrie Martin, A. Buckler-White, K. Wollenberg, C. Kozak   +3 more
semanticscholar   +5 more sources

Matrix Fibronectin Binds Gammaretrovirus and Assists in Entry: New Light on Viral Infections [PDF]

Journal of Virology, 2007
ABSTRACT A major entry route for the gammaretrovirus amphotropic murine leukemia virus (A-MLV) into NIH 3T3 fibroblasts is via caveola-dependent endocytosis. However, during the infection time, few viral particles can be observed intracellularly.
C. Beer, L. Pedersen
semanticscholar   +6 more sources

piRNA Defense Against Endogenous Retroviruses [PDF]

Viruses
Infection by retroviruses and the mobilization of transposable elements cause DNA damage that can be catastrophic for a cell. If the cell survives, the mutations generated by retrotransposition may confer a selective advantage, although, more commonly ...
Milky Abajorga, Leonid Yurkovetskiy, Jeremy Luban   +2 more
doaj   +2 more sources

Mutations altering the gammaretrovirus endoproteolytic motif affect glycosylation of the envelope glycoprotein and early events of the virus life cycle.

Virology, 2015
Previously, we found that mutation of glutamine to proline in the endoproteolytic cleavage signal of the PERV-C envelope (RQKK to RPKK) resulted in non-infectious vectors. Here, we show that RPKK results in a non-infectious vector when placed in not only a PERV envelope, but also the envelope of a related gammaretrovirus, FeLV-B.
Takele Argaw, Carolyn Wilson
semanticscholar   +5 more sources