Partial Molecular Cloning of the JHK Retrovirus Using Gammaretrovirus Consensus PCR Primers [PDF]
Future Virology, 2013 The JHK virus (JHKV) was previously described as a type C retrovirus that has some distinctive ultrastructural features and replicates constitutively in a human B-lymphoblastoid cell line, JHK-3. In order to facilitate the cloning of sequences from JHKV, a series of partially degenerate consensus retroviral PCR primers were created by a data-driven ...
Brian Halligan +3 more
semanticscholar +5 more sources
Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [PDF]
eLife, 2017 Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Daniel Blanco-Melo +2 more
doaj +4 more sources
Genomics, 2019 Endogenous retroviruses (ERVs) constitute a significant part of vertebrate genomes. They originated from past retroviral infections and some of them retain transcriptional activity. The key mechanism avoiding uncontrolled ERV transcription is DNA methylation-mediated epigenetic silencing.
T. Hron, H. Fábryová, D. Elleder
semanticscholar +4 more sources
Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Virology, 2010 Recently, the first human infection with an exogenous gammaretrovirus (XMRV) was reported. In its initial description, XMRV was confined to prostate stromal fibroblasts, although subsequent reports demonstrated XMRV protein expression in prostate epithelial cells.
K. Stieler +5 more
semanticscholar +3 more sources
Characterization of HIV-1 vectors with gammaretrovirus envelope glycoproteins produced from stable packaging cells [PDF]
Gene Therapy, 2004 We have recently described a novel, stable human immunodeficiency virus type 1 (HIV-1) vector packaging system, STAR. High-titre HIV-1 vectors bearing gammaretrovirus envelopes (Env) are continuously produced from STAR cells. Here we compare the properties of such vectors, with the amphotropic murine leukaemia virus (MLV-A) Env, a modified gibbon ape ...
B. L. Strang +4 more
semanticscholar +3 more sources
Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project [PDF]
Molecular Therapy: Oncolytics, 2022 The Chimeric Antigen Receptor (CAR) T Cell Safety Database Project explored the use of cross-study safety data to identify risk factors associated with severe cytokine release syndrome (sCRS) and severe neurological toxicities (sNTX) after CAR T cell ...
Matthew Foster +7 more
doaj +2 more sources
The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteins [PDF]
bioRxiv, 2020 Host genomes have acquired diversity from viruses through the capture of viral elements, often from endogenous retroviruses (ERVs). These viral elements contribute new transcriptional control elements and new protein encoding genes, and their refinement ...
Kevin R. McCarthy +6 more
openalex +2 more sources
Vaccination studies with the mper of HIV-1 gp41 grafted into transmembrane protein of a gammaretrovirus [PDF]
, 2013 A vaccine against HIV-1 to keep the pandemic in bay is one of the major goals in vaccine development. Although the scientific field of vaccine development is largely supported with extensive fundings, attempts to design a vaccine to induce potent protection only remained successful in the macaque model, but not in human trials. In order to address this
Nicola Strasz
semanticscholar +4 more sources
The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice [PDF]
Journal of Virology, 2013 Carrie Martin +3 more
openalex +2 more sources