Crystal Structures of Beta- and Gammaretrovirus Fusion Proteins Reveal a Role for Electrostatic Stapling in Viral Entry [PDF]
Journal of Virology, 2013 ABSTRACT Membrane fusion is a key step in the life cycle of all envelope viruses, but this process is energetically unfavorable; the transmembrane fusion subunit (TM) of the virion-attached glycoprotein actively catalyzes the membrane merger process. Retroviral glycoproteins are the prototypical system to study pH-independent viral entry.
H. Aydin, J. D. Cook, Jeffrey E. Lee
semanticscholar +5 more sources
Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus [PDF]
Proceedings of the National Academy of Sciences, 2009 The Fv1 virus resistance gene is a coopted endogenous retrovirus (ERV) sequence related to the gag gene of the MuERV-L ERV family. Three major Fv1 resistance alleles have been identified in laboratory mice, and they target virus capsid genes to produce characteristic ...
Yuhe Yan +3 more
semanticscholar +5 more sources
Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project [PDF]
Molecular Therapy: Oncolytics, 2022 The Chimeric Antigen Receptor (CAR) T Cell Safety Database Project explored the use of cross-study safety data to identify risk factors associated with severe cytokine release syndrome (sCRS) and severe neurological toxicities (sNTX) after CAR T cell ...
Matthew Foster +7 more
doaj +2 more sources
Transduction of Nondividing Human Macrophages with Gammaretrovirus-Derived Vectors [PDF]
Journal of Virology, 2006 ABSTRACT It is commonly accepted that infection of nondividing cells by gammaretroviruses such as the murine leukemia viruses is inefficient due to their inability to cross the nuclear envelope barrier. Challenging this notion, we now show that human nondividing macrophages display a specific window of susceptibility to transduction with a ...
Loraine Jarrosson-Wuillème +5 more
openalex +4 more sources
Spontaneous Heteromerization of Gammaretrovirus Envelope Proteins: a Possible Novel Mechanism of Retrovirus Restriction [PDF]
Journal of Virology, 2008 ABSTRACT The env gene of gammaretroviruses encodes a glycoprotein conserved among diverse retroviruses, except for the domains involved in receptor binding. Here we show that pairs of gammaretrovirus envelope proteins (from Friend virus and GALV or xenotropic viruses) assemble into heteromers when ...
Marie Dewannieux, Mary Collins
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Ancient invasion of an extinct gammaretrovirus in cetaceans.
Virology, 2013 Endogenous gammaretroviruses (EGVs) have been widely studied in terrestrial mammals but seldom so in marine species. A genomic mining of the bottlenose dolphin (Tursiops truncatus) genome revealed a new EGV, termed Tursiops truncatus endogenous retrovirus (TTEV), which is divergent from extant mammalian EGVs.
Lina Wang +5 more
semanticscholar +4 more sources
Control of Pathogenicity and Disease Specificity of a T-Lymphomagenic Gammaretrovirus by E-Box Motifs but Not by an Overlapping Glucocorticoid Response Element [PDF]
Journal of Virology, 2008 ABSTRACTAlthough transcription factors of the basic helix-loop-helix family have been shown to regulate enhancers of lymphomagenic gammaretroviruses through E-box motifs, the overlap of an E-box motif (Egre) with the glucocorticoid response element (GRE) has obscured their function in vivo.
Ditte Møller Ejegod +5 more
openalex +6 more sources
Construction of a Gammaretrovirus with a Novel Tropism and Wild-Type Replication Kinetics Capable of Using Human APJ as Entry Receptor [PDF]
Journal of Virology, 2012 S. Bahrami +5 more
semanticscholar +2 more sources
Virology, 2015 Endogenous retroviruses (ERVs) were acquired during evolution of their host organisms after infection and mendelian inheritance in the germline by their exogenous counterparts. The ERVs can spread in the host genome and in some cases they affect the host phenotype. The cervid endogenous gammaretrovirus (CrERV) is one of only a few well-defined examples
H. Fábryová +4 more
semanticscholar +5 more sources