Spontaneous Heteromerization of Gammaretrovirus Envelope Proteins: a Possible Novel Mechanism of Retrovirus Restriction [PDF]
Journal of Virology, 2008 ABSTRACT The env gene of gammaretroviruses encodes a glycoprotein conserved among diverse retroviruses, except for the domains involved in receptor binding. Here we show that pairs of gammaretrovirus envelope proteins (from Friend virus and GALV or xenotropic viruses) assemble into heteromers when ...
Marie Dewannieux, Mary Collins
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Transduction of Nondividing Human Macrophages with Gammaretrovirus-Derived Vectors [PDF]
Journal of Virology, 2006 ABSTRACT It is commonly accepted that infection of nondividing cells by gammaretroviruses such as the murine leukemia viruses is inefficient due to their inability to cross the nuclear envelope barrier. Challenging this notion, we now show that human nondividing macrophages display a specific window of susceptibility to transduction with a ...
Loraine Jarrosson-Wuillème +5 more
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Proceedings of the National Academy of Sciences of the United States of America, 2009 Yuhe Yan +3 more
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Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer. [PDF]
Protein SciAbstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Kapisheva M +6 more
europepmc +2 more sources
Adaptive Evolution of a Tagged Chimeric Gammaretrovirus: Identification of Novel cis-Acting Elements that Modulate Splicing [PDF]
Journal of Molecular Biology, 2007 Retroviruses are well known for their ability to incorporate envelope (Env) proteins from other retroviral strains and genera, and even from other virus families. This characteristic has been widely exploited for the generation of replication-defective retroviral vectors, including those derived from murine leukemia virus (MLV), bearing heterologous ...
Christopher R. Logg +3 more
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Construction of a Gammaretrovirus with a Novel Tropism and Wild-Type Replication Kinetics Capable of Using Human APJ as Entry Receptor [PDF]
Journal of Virology, 2012 Shervin Bahrami +5 more
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Immunisation with the membrane proximal external region of gp41 of HIV-1 grafted into the transmembrane envelope protein of a gammaretrovirus [PDF]
Retrovirology, 2012 Background Immunisation with the transmembrane envelope (TM) proteins p15E of different gammaretroviruses (e.g., porcine endogenous retrovirus, feline leukaemia virus, Koala retrovirus) resulted in strong neutralising activity, the antibodies recognised ...
Nicola Strasz +4 more
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A natural human retrovirus efficiently complements vectors based on murine leukemia virus. [PDF]
PLoS ONE, 2008 Murine Leukemia Virus (MLV) is a rodent gammaretrovirus that serves as the backbone for common gene delivery tools designed for experimental and therapeutic applications.
Beihua Dong +2 more
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An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]
, 2000 : Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus +57 more
core +10 more sources
Viral vector‐based cancer treatment and current clinical applications
MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023 Adenovirus, adeno‐associated virus, herpes simplex virus, and retrovirus have been utilized for cancer treatment. Ex vivo treatment: cells isolated from the patients are genetically modified by viral vectors and then transfused back into patients.
Lingwan Xie +6 more
wiley +1 more source