The role of viruses in cancer development versus cancer therapy: An oncological perspective
Virotherapy agents as novel potential agents in the field of cancer therapy are one of the new emerging therapeutic approaches that attract attention in this field. One of the concerning factors is the role of viruses in cancer development, which needed to be explored against their anticancer applications.
Hossein Javid+7 more
wiley +1 more source
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. [PDF]
A newly discovered gammaretrovirus, termed XMRV, was recently reported to be present in the prostate cancer cell line CWR22Rv1. Using a combination of both immunohistochemistry with broadly-reactive murine leukemia virus (MLV) anti-sera and PCR, we ...
Karen Sandell Sfanos+10 more
doaj +1 more source
Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications
Abstract Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have been co‐opted in human physiological functions while their aberrant ...
Konstantina Kitsou+2 more
wiley +1 more source
Health surveillance of wildlife populations is essential for conservation and reduction of the impacts of disease. Population declines and areas of overabundance of koalas (Phascolarctos cinereus) can disrupt the overall survival of the species as well as its habitat. This retrospective study was conducted to describe population distributions, identify
M Cooley+3 more
wiley +1 more source
Mammalian genomes typically contain hundreds of thousands of endogenous retroviruses (ERVs), derived from ancient retroviral infections. Using this molecular 'fossil' record, we reconstructed the natural history of a specific retrovirus lineage (ERV-Fc ...
William E Diehl+3 more
doaj +1 more source
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman+17 more
doaj +1 more source
Phylogenetic and structural diversity in the feline leukemia virus env gene. [PDF]
Feline leukemia virus (FeLV) belongs to the genus Gammaretrovirus, and causes a variety of neoplastic and non-neoplastic diseases in cats. Alteration of viral env sequences is thought to be associated with disease specificity, but the way in which ...
Shinya Watanabe+8 more
doaj +1 more source
Understanding the Enigmatic Dance of Immune-Mediated Viral Infections and Their Pathogenetic Mechanisms. [PDF]
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Karabulut MC, Oğuzoğlu TÇ.
europepmc +2 more sources
P1400: THREE YEARS OUTCOMES OF PRIMARY MEDIASTINAL B CELL LYMPHOMA PATIENTS FOLLOWING ANTI CD19 CAR-T CELL THERAPY - A SINGLE CENTER EXPERIENCE [PDF]
HemaSphere, Volume 7, Issue S3, August 2023.
Geva M+13 more
europepmc +2 more sources
Recruitment of dynein and kinesin to viral particles
Abstract Dynein and kinesin are cytoskeletal motor proteins involved in transporting cellular cargos and viruses. Throughout viral infection, they actively participate in the virus life cycle in the cell during entry, genome replication, and departure.
Sayi’Mone Tati, Laleh Alisaraie
wiley +1 more source