Results 121 to 130 of about 238,953 (314)
Advanced Science, EarlyView.In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu +16 more
wiley +1 more source
The substantia Nigra pars compacta and temporal processing
, 2006 The basal ganglia and cerebellum are considered to play a role in timing, although their differential roles in timing remain unclear. It has been proposed that the timing of short milliseconds-range intervals involves the cerebellum, whereas longer ...
Dirnberger, G. +3 more
core
, 2008 In contrast to the current belief that angiotensin II (Ang II) interacts with the sympathetic nervous system only as a circulating hormone, we document here the existence of endogenous Ang II in the neurons of rat and human sympathetic coeliac ganglia ...
Imboden, Hans +4 more
core +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Modeling serotonin's contributions to basal ganglia dynamics
, 2018 In addition to dopaminergic input, serotonergic (5-HT) fibers also widely arborize through the basal ganglia circuits and strongly control their dynamics.
Ravindran, Balaraman +3 more
core
Advanced Science, EarlyView.Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan +8 more
wiley +1 more source
Evidence for lesions to the basal ganglia lead to perceptual priming impairment
, 2000 Little is know about the cognitive function of the basal ganglia.This study presents our experimental results with three patients(one with focal lesions to the right basal ganglia,other two with impairment to bilateral basal ganglia and hippocampus or ...
D. He, S. Y. Yu, C. S. Wang
core
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
, 2015 Astrocytes are important regulatory elements in brain function. They respond to neurotransmitters and release gliotransmitters that modulate synaptic transmission.
Perea, Gertrudis +4 more
core +1 more source