Results 131 to 140 of about 238,953 (314)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

INSIGHTS FROM LAMPREY INTO DEVELOPMENT AND EVOLUTION OF GLIA AND CRANIAL SENSORY GANGLIA [PDF]

, 2018
During evolution, animal nervous systems have become increasingly complex. This complexity is based on the cumulative diversity of neural cells and the emergence of new nervous system structures.
Yuan, Tian
core  

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia

, 2009
To clarify the role of Angiotensin II (Ang II) in the sensory system and especially in the trigeminal ganglia, we studied the expression of angiotensinogen (Ang-N)-, renin-, angiotensin converting enzyme (ACE)- and cathepsin D-mRNA, and the presence of ...
Patil, J., Imboden, H., Wellner, Maren, Hess, B., Ahmed, Nermin, Wellner, M., Nussberger, Juerg, Senbonmatsu, Takaaki, Müller, D., Patil, Jaspal, Saavedra, Juan M., Müller, Dominik, Inagami, Tadashi, Senbonmatsu, T., Nicoud, F., Inagami, T., Nicoud, Françoise, Schaffner, T., Ahmed, N., Pavel, Jaroslav, Imboden, Hans, Saavedra, J.M., Hess, Benno, Schaffner, Thomas, Pavel, J., Nussberger, J.   +25 more
core   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Guia de instalação do Ganglia. [PDF]

, 2013
Ganglia Monitoring Daemon (gmond). Ganglia Meta Daemon (gmetad). Ganglia PHP Web Front-end. Instalação. Regras de Firewall. Configuração de um cluster. Multicast. Unicast.
VIEIRA, F. D.
core  

Ganglia. [PDF]

BMJ, 1977
openaire   +4 more sources

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Modeling sertonin's contributions to basal ganglia dynamics in Parkinson's disease with impulse control disorders

, 2018
Impulsivity involves irresistibility in execution of actions and is prominent in medication condition of Parkinson’s disease (PD) patients. In this chapter, we model a probabilistic reversal learning task in PD patients with and without impulse control ...
V. Srinivasa Chakravarthy, Ravindran, Balaraman, Chakravarthy, Srinivasa, Ahmed A. Moustafa, Pragathi Priyadharsini Balasubramani, Balaraman Ravindran, Moustafa, Ahmed A. (R17078), Balasubramani, Pragathi P.   +7 more
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source