Results 131 to 140 of about 227,324 (313)
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
P2X7 Receptor Modulation of Visual Responses in the Retina [PDF]
, 2015 Adenosine 5’ triphosphate (ATP)-gated P2X7 receptors (P2X7Rs) are known to act as conduits for photoreceptor and retinal ganglion cell (RGC) damage, consequences of various neurodegenerative conditions within the visual pathway. Growing evidence supports
Chavda, S
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Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Hypoxia-ischemia and retinal ganglion cell damage
, 2008 Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling11Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, SingaporeAbstract: Retinal hypoxia is the potentially blinding ...
Eng-Ang Ling +2 more
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Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Neural Regeneration ResearchRetinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall +7 more
doaj +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
Dorsal root ganglion – a potential new therapeutic target for neuropathic pain
, 2012 Damir Sapunar, Sandra Kostic, Adriana Banozic, Livia PuljakDepartment of Anatomy, Histology, and Embryology, University of Split Medical School, Soltanska 2, 21000 Split, CroatiaAbstract: A regional approach can protect our patients from often ...
Banozic A, Puljak L, Kostic S, Sapunar D
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Advanced Science, EarlyView.HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li +8 more
wiley +1 more source
Advanced Science, EarlyView.In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang +13 more
wiley +1 more source