Results 71 to 80 of about 892,023 (265)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Materials Research Express, 2020 In this work, ${{\rm{Bi}}}_{0.8}{{\rm{Ba}}}_{0.2}{{\rm{Fe}}}_{1-x}{{\rm{Mo}}}_{x}{{\rm{O}}}_{3}$ (x = 0, 0.5, 0.10 and 0.15) ceramics were synthesized by conventional solid-state reaction to evaluate the influence of Ba ^2+ and Mo ^6+ co-doping on the ...
Aungkan Sen +6 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Forest EcosystemsContinuous cover forestry is gaining importance in temperate forests as an alternative to rotation forestry. However, for light-demanding oaks, especially when coexisting with shade-tolerant tree species, the optimal gap size and shape for successful ...
Flóra Tinya +6 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Planets in the Radius Gap Lack the Peas-in-a-pod Size Correlation
The Astronomical JournalPlanets in compact multitransiting systems tend to exhibit self-similarity with their neighbors, a phenomenon commonly called “peas-in-a-pod.” Previous studies have identified that this self-similarity appears independently among super-Earths and sub ...
Quadry Chance, Sarah Ballard
doaj +1 more source
Particle Attrition in Small Clearances
KONA Powder and Particle Journal, 2014 Attrition is commonly found in the clearances of equipment where a mechanical device moves relative to a wall. Particles are trapped and broken in these regions, hence promoting attrition.
C.C. Crutchley, J. Bridgwater
doaj +1 more source