Results 131 to 140 of about 6,730,942 (304)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Mechanical Comparison of the Compressive Force Generated by Various Headless Compression Screws and the Impact of Fracture Gap Size. [PDF]
Hand (N Y), 2021 Ilyas AM, Mahoney JM, Bucklen BS.
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2011 cedric.plont@gmail.com Doctorant en Science Politique sous la direction de Bernard Lacroix (GAP) et Yves Déloye (CRPS) : « La construction de l’Etat, cérémonies royales et les bourgeois de Paris entre les XVIe et XVIIIe siècles : Emergence politique d’un
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Gap size effects on centrifugally and rotationally driven instabilities
, 1992 International audienceThe rotation effects on centrifugally driven instabilities in curved channel flow with a finite gap are investigated. An inviscid criterion of stability is formulated to explain the behavior of the flow when rotation and curvature ...
Wesfreid, Eduardo +5 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
GAP SS&H Newsletter (Vol 2 Issue 1)
, 2013 GAP SS&H Newsletter Volume 2 Issue
GAP SSHRC
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Gap Dependent Bifurcation Behavior of a Nano-Beam Subjected to a Nonlinear Electrostatic Pressure
Latin American Journal of Solids and StructuresThis paper presents a study on the gap dependent bifurcation behavior of an electro statically-actuated nano-beam. The sizedependent behavior of the beam was taken into account by applying the couple stress theory.
Mohammad Fathalilou +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source