Results 191 to 200 of about 5,123,013 (349)

Anais Brasileiros de Dermatologia. Beginning a new five-year term, 2026-2030. [PDF]

An Bras Dermatol
Almeida HL.
europepmc   +1 more source

Wind Gaps [PDF]

Science, 1915
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The expanding roles of homologous recombination proteins in genome stability. [PDF]

EMBO J
Sassi L, Martinez Marroquin A, Waked S, Ardizzoia A, Costanzo V.   +4 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The racial and ethnic gap in behavioral measures rivals the gender gap in the United States. [PDF]

Proc Natl Acad Sci U S A
Dariel A, Ham JC, Nikiforakis N, Stoop J.   +3 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

An Accurate Alternative to Hybrid Functionals for Germanium: DFT+α. [PDF]

J Phys Chem C Nanomater Interfaces
Abdurrazaq A, Lot R, Jay A, Herrero-Saboya G, Richard N, Martin-Samos L, Hémeryck A, de Gironcoli S.   +7 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Robotic-Assisted Dynamic Intraoperative Assessment of Coronal Plane Stability Across the Range of Motion During Total Knee Arthroplasty. [PDF]

J Orthop Case Rep
Rajashekhar KT, Bhat AKK, Bagrecha A.
europepmc   +1 more source