Results 1 to 10 of about 21,628 (300)

Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. [PDF]

Biomedicines
This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins
Zubareva T, Mironova E, Panfilova A, Krylova Y, Mazzoccoli G, Marasco MGP, Kvetnoy I, Yablonsky P.   +7 more
europepmc   +5 more sources

Connexins are mechanosensitive

American Journal of Physiology-Cell Physiology, 2004
Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes.
Dahl, Gerhard, Bao, Li, Sachs, Frederick   +2 more
core   +3 more sources

Mitochondrial Connexins and Mitochondrial Contact Sites with Gap Junction Structure

, 2023
Mitochondria contain connexins, a family of proteins that is known to form gap junction channels. Connexins are synthesized in the endoplasmic reticulum and oligomerized in the Golgi to form hemichannels.
Sharon C. Francis, Sandra A. Murray, Anthonya T. Cooper, Selma Cetin-Ferra, Andrea G. Marshall, Antentor Hinton, Kit Neikirk   +6 more
core   +1 more source

Role of connexins and pannexins in cardiovascular physiology [PDF]

, 2021
Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology.
Duffy, Heather, Kwak, Brenda, Meens, Merlijn   +2 more
core  

Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]

, 2003
Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Gap-junctional coupling between neutrophils and endothelial cells [PDF]

, 2003
Communication between leukocytes and endothelial cells is crucial for inflammatory reactions. Paracrine cross-talk and outside-in signaling (via adhesion molecules) have been characterized as communication pathways to date.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Connexins in colorectal cancer pathogenesis

, 2015
International audience: The connexins constitute a family of integral membrane proteins that form channels between adjacent cells. These channels are assembled in plasma membrane domains known as gap junctions and enable cells to directly exchange ions ...
Jarle Bruun, Lothe, Ragnhild A, Edgar Rivedal, Bruun, Jarle, Mesnil, Marc, Matthias Kolberg, Fykerud, Tone A, Lind, Guro E, Sirnes, Solveig, Marc Mesnil, Kolberg, Matthias, Ragnhild A. Lothe, Guro E. Lind, Tone A. Fykerud, Rivedal, Edgar, Edward Leithe, Solveig Sirnes, Leithe, Edward   +17 more
core   +1 more source

Connexins: Sensors of epidermal integrity that are therapeutic targets

, 2014
Gap junction proteins (connexins) are differentially expressed throughout the multiple layers of the epidermis. A variety of skin conditions arise with aberrant connexin expression or function and suggest that maintaining the epidermal gap junction ...
Wright, Catherine S, Martin, Patricia E, Martin, Patricia E., Hodgins, Malcolm B., Wright, Catherine S.; id_orcid, Hodgins, Malcolm B, Easton, Jennifer A., Easton, Jennifer A, Wright, Catherine S.   +8 more
core   +1 more source

Mind the gap: connexins and pannexins in platelet function [PDF]

, 2021
Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Gibbins, Jonathan M., Taylor, Kirk A., Jonathan M. Gibbins, Little, Gemma, Kirk a Taylor, Gemma Little   +5 more
core   +1 more source

Cardiac connexins and impulse propagation

, 2010
Gap junctions form the intercellular pathway for cell-to-cell transmission of the cardiac impulse from its site of origin, the sinoatrial node, along the atria, the atrioventricular conduction system to the ventricular myocardium.
van Rijen, Harold V. M., de Bakker, Jacques M. T., van Veen, Toon A. B., Jansen, John A.   +3 more
core   +1 more source