Results 1 to 10 of about 11,327 (216)
Connexins in Cancer: Jekyll or Hyde?
Biomolecules, 2020 The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin Mulkearns-Hubert +2 more
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The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance
Biology, 2023 Today’s research on the processes of carcinogenesis and the vital activity of tumor tissues implies more attention be paid to constituents of the tumor microenvironment and their interactions.
Irina Balalaeva +2 more
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Coordination of innate immune responses by connexins [PDF]
Frontiers in ImmunologyInnate immunity comprises intricate cellular and tissue responses critical for host defense and tissue homeostasis. Intercellular communication is central to these responses and significantly influences infection, inflammatory disorders, and cancer ...
Qirou Wu +4 more
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The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches
Frontiers in Physiology, 2016 Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites.
, TERESA Tan, Wing Tak Wong
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Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications [PDF]
BiomedicinesThis article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins
Tatiana Zubareva +7 more
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Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate [PDF]
Scientific ReportsMembrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of ...
Makoto Hosoya +6 more
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Frontiers in Cellular Neuroscience, 2023 Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema
Cyrine Ben Dhaou +8 more
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Cells, 2023 Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds’ structurally different ortho- and
Kinga Skieresz-Szewczyk, Hanna Jackowiak
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Astroglial Connexins in Neurodegenerative Diseases
Frontiers in Molecular Neuroscience, 2021 Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang +8 more
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Biomolecules, 2023 Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li +2 more
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