Results 1 to 10 of about 38,435 (285)
Connexins in Cancer: Jekyll or Hyde?
Biomolecules, 2020 The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E Mulkearns-Hubert +2 more
exaly +4 more sources
Journal of Biomedical Science, 2019 Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions among neighboring cells and thus facilitates gap junctional intercellular communication (GJIC).
Lu‐Hai Wang
exaly +4 more sources
Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease [PDF]
International Journal of Molecular Sciences, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Trond Aasen +2 more
exaly +6 more sources
The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance
Biology, 2023 Today’s research on the processes of carcinogenesis and the vital activity of tumor tissues implies more attention be paid to constituents of the tumor microenvironment and their interactions.
Olga M. Kutova +2 more
doaj +2 more sources
Astroglial Connexins in Neurodegenerative Diseases
Frontiers in Molecular Neuroscience, 2021 Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang +8 more
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Atrial Fibrillation: Focus on Myocardial Connexins and Gap Junctions
Biology, 2022 Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia worldwide and contributes to substantial morbidity, mortality and socioeconomic burden. Aggregating evidence highlights the strong genetic basis of AF. In addition to
Yu-Han Guo, Yi-Qing Yang
doaj +2 more sources
Extracellular cysteine in connexins: Role as redox sensors [PDF]
Frontiers in Physiology, 2016 Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D. +7 more
core +3 more sources
Connexins : substrates and regulators of autophagy [PDF]
BMC Cell Biology, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +2 more sources
Endothelial connexins in vascular function
Vascular Biology, 2019 Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the ...
Aurélie Hautefort +2 more
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Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets
Frontiers in Physiology, 2017 Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by ...
Nunzio Vicario +7 more
doaj +2 more sources