Zearalenone Induces Gap Junction Damage in Ovine Ovarian Granulosa Cells by Upregulating GPR30 and Activating the Oxidative Stress–NLRP3 Inflammasome Axis [PDF]
BiomoleculesOvarian granulosa cells (GCs) ensure proper follicular development and oocyte maturation through gap-junction-mediated intercellular communication. Zearalenone (ZEA), a mycotoxin with estrogen-like activity, specifically targets and impairs ovarian ...
Xiaoyun Pang +9 more
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Src Regulation of Cx43 Phosphorylation and Gap Junction Turnover
Biomolecules, 2020 The gap junction protein Connexin43 (Cx43) is highly regulated by phosphorylation at over a dozen sites by probably at least as many kinases. This Cx43 “kinome” plays an important role in gap junction assembly and turnover.
Joell L. Solan, Paul D. Lampe
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Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review [PDF]
Frontiers in Cell and Developmental BiologyThe gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body.
Lulu Fu +5 more
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis
Basic and Clinical Andrology, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Dominique Segretain +5 more
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Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. [PDF]
PLoS ONE, 2014 Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in ...
Yoshinobu Kidokoro +6 more
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Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling [PDF]
CellRyan Camire
exaly +2 more sources
Gap junction plasticity as a mechanism to regulate network-wide oscillations. [PDF]
PLoS Computational Biology, 2018 Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in
Guillaume Pernelle +2 more
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An Information Theoretical Analysis of Gap Junction Channels
IEEE Access, 2021 The propagation of molecules, ions and electrochemical signals in various cell types occurs through hundreds of gap junction channels. A gap junction channel is composed of hundreds of units which are further decomposed to hemichannels.
Farrokh Hejri +2 more
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Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. [PDF]
PLoS ONE, 2014 Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder ...
Takeshi Okinami +8 more
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Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. [PDF]
PLoS Computational Biology, 2016 Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile ...
Aleena M Notary +4 more
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