Definitions, 2020 Intercellular connections comprised of complexes of connexin family proteins that permit the transfer of cytoplasmic ions and molecules between connected cells. Each cell contains a hemichannel made up of homo- or hetero-hexamers of connexins.
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Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
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Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review [PDF]
Frontiers in Cell and Developmental BiologyThe gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body.
Lulu Fu +5 more
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Zearalenone Induces Gap Junction Damage in Ovine Ovarian Granulosa Cells by Upregulating GPR30 and Activating the Oxidative Stress–NLRP3 Inflammasome Axis [PDF]
BiomoleculesOvarian granulosa cells (GCs) ensure proper follicular development and oocyte maturation through gap-junction-mediated intercellular communication. Zearalenone (ZEA), a mycotoxin with estrogen-like activity, specifically targets and impairs ovarian ...
Xiaoyun Pang +9 more
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Current Biology, 2013 In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling ...
Shimizu, Kazumichi, Stopfer, Mark
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Transfer of mitochondria and endosomes between cells by gap junction internalization
Traffic : the International Journal of Intracellular Transport, 2021 Intercellular organelle transfer has been documented in several cell types and has been proposed to be important for cell‐cell communication and cellular repair. However, the mechanisms by which organelle transfer occurs are uncertain.
R. Norris
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Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling [PDF]
CellRyan Camire
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Cold Spring Harbor Perspectives in Biology, 2009 Gap junctions are aggregates of intercellular channels that permit direct cell-cell transfer of ions and small molecules. Initially described as low-resistance ion pathways joining excitable cells (nerve and muscle), gap junctions are found joining virtually all cells in solid tissues.
Daniel A, Goodenough, David L, Paul
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis
Basic and Clinical Andrology, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Dominique Segretain +5 more
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Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. [PDF]
PLoS ONE, 2014 Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in ...
Yoshinobu Kidokoro +6 more
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