Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies [PDF]
Journal of Cell Biology, 1992 We examined the roles of the extracellular domains of a gap junction protein and a cell adhesion molecule in gap junction and adherens junction formation by altering cell interactions with antibody Fab fragments.
Johnson, Ross G. +3 more
core +4 more sources
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling. [PDF]
CellKrolak T +10 more
europepmc +2 more sources
Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. [PDF]
PLoS ONE, 2014 Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder ...
Takeshi Okinami +8 more
doaj +1 more source
Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. [PDF]
PLoS Computational Biology, 2016 Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile ...
Aleena M Notary +4 more
doaj +1 more source
Frontiers in Physiology, 2022 In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis.
Nikki L. Farnsworth +11 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2023 Gap junctions, which are mainly composed of connexin units, play an indispensable role in cell morphogenesis, proliferation, migration, adhesion and differentiation of osteoblast lineage cells, and thus mediate bone development, homeostasis and disease ...
Tao Zuo +6 more
doaj +1 more source
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. [PDF]
PLoS Genetics, 2016 Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear.
Lingfeng Meng, Chia-hui Chen, Dong Yan
doaj +1 more source
Alteration of cell junctions during viral infection
Thoracic Cancer, 2020 Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment.
Dan Dong, Wei Xie, Min Liu
doaj +1 more source
Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
doaj +1 more source
PLoS Biology, 2020 Gap junction connections between neurons play critical roles in the development of the nervous system. However, studies on the sensory experience-driven plasticity during the critical period rarely examine the involvement of gap junction connections.
Li Zhang, Qiwen Wu, Yifeng Zhang
doaj +1 more source