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Current Biology, 2013 In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling ...
Shimizu, Kazumichi, Stopfer, Mark
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Biotin-cGMP and -cAMP are able to permeate through the gap junctions of some amacrine cells in the mouse retina despite their large size [PDF]
Frontiers in Ophthalmology, 2023 Gap junctions transmit electrical signals in neurons and serve metabolic coupling and chemical communication. Gap junctions are made of intercellular channels with large pores, allowing ions and small molecules to permeate.
Chunxu Yuan +6 more
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Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier [PDF]
Frontiers in Neurology, 2023 IntroductionThe movement of fluids and solutes across the ependymal barrier, and their changes in physiologic and disease states are poorly understood.
Riccardo Serra +3 more
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Gap Junctions in C. elegans [PDF]
Frontiers in Physiology, 2014 As in other multicellular organisms, the nematode Caenorhabditis elegans uses gap junctions to provide direct cell-to-cell contact. The nematode gap junctions are formed by innexins (invertebrate analogs of the connexins); a family of proteins that ...
Karina eSimonsen +3 more
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Astrocyte gap junctions and Kir channels contribute to K+ buffering and regulate neuronal excitability [PDF]
Frontiers in Cellular NeuroscienceAstrocytes are connected in a functional syncytium via gap junctions, which contribute to the maintenance of extracellular K+ homeostasis. The prevailing hypothesis is that K+ released during neuronal firing is taken up by astrocytes via Kir channels and
Danica Bojovic +6 more
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Gap junctions and epileptic seizures--two sides of the same coin? [PDF]
PLoS ONE, 2011 Electrical synapses (gap junctions) play a pivotal role in the synchronization of neuronal ensembles which also makes them likely agonists of pathological brain activity.
Vladislav Volman +2 more
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Contribution of large-pore channels to inflammation induced by microorganisms
Frontiers in Cell and Developmental Biology, 2023 Plasma membrane ionic channels selectively permeate potassium, sodium, calcium, and chloride ions. However, large-pore channels are permeable to ions and small molecules such as ATP and glutamate, among others.
José L. Vega +6 more
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Cold Spring Harbor Perspectives in Biology, 2009 Gap junctions are aggregates of intercellular channels that permit direct cell-cell transfer of ions and small molecules. Initially described as low-resistance ion pathways joining excitable cells (nerve and muscle), gap junctions are found joining virtually all cells in solid tissues.
Daniel A, Goodenough, David L, Paul
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The Journal of Cell Biology, 2005 In the 1960s there was adhesion and there was direct current transfer—a strange neuronal phenomenon whose mechanism was unknown. The two fields only gradually drifted together, but with the report by Revel and Karnovsky (1967) they were united around a distinct, structural correlate soon to ...
William A, Wells, Laura, Bonetta
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Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals
eLife, 2022 Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways.
Munenori Ishibashi +10 more
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