Possible role of hemichannels in cancer [PDF]
Frontiers in Physiology, 2014 In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors.
Kurt A Schalper
exaly +5 more sources
Extracellular cysteine in connexins: role as redox sensors [PDF]
Frontiers in Physiology, 2016 Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal +7 more
doaj +4 more sources
Frontiers in Cell and Developmental Biology, 2023 Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly ...
Dezhi Zhao +6 more
doaj +2 more sources
Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
The Journal of Clinical Investigation, 2023 Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert +8 more
doaj +2 more sources
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]
Frontiers in Physiology, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Catheleyne eD'hondt +4 more
doaj +4 more sources
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Biological Research, 2023 Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection ...
Juan Prieto-Villalobos +5 more
doaj +2 more sources
Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens
Frontiers in Physiology, 2022 Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular ...
Mauricio A. Retamal +3 more
doaj +2 more sources
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Biological ResearchBackground Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption
Gonzalo I. Gómez +12 more
doaj +2 more sources
Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis [PDF]
Redox BiologyRedox homeostasis and transparency in the ocular lens are closely associated with the distribution of the antioxidant reduced glutathione (GSH).
Guangyan Wang +4 more
doaj +2 more sources
Frontiers in Physiology, 2020 Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively.
Vania A. Figueroa +13 more
doaj +2 more sources