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Mechanisms Underlying Connexin Hemichannel Activation in Disease [PDF]

International Journal of Molecular Sciences, 2021
Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their ...
Raf Van Campenhout, Timo W M De Groof, Serge V Muyldermans   +2 more
exaly   +5 more sources

Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome

Scientific Reports, 2021
Mutations in five different genes encoding connexin channels cause eleven clinically defined human skin diseases. Keratitis ichthyosis deafness (KID) syndrome is caused by point mutations in the GJB2 gene encoding Connexin 26 (Cx26) which result in ...
Caterina Sellitto, Leping Li, Thomas W. White   +2 more
doaj   +2 more sources

Bracovirus-mediated innexin hemichannel closure in cell disassembly

iScience, 2021
Summary: Cell-cell communication is necessary for cellular immune response. Hemichannel closure disrupts communication between intracellular and extracellular environments during polydnavirus-induced immunosuppression in invertebrates.
Chang-Xu Chen, Hao-Juan He, Qiu-Chen Cai, Wei Zhang, Tian-Chao Kou, Xue-Wen Zhang, Shan You, Ya-Bin Chen, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo   +11 more
doaj   +2 more sources

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Journal of Clinical Investigation, 2021
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known on potential roles of hemichannels ...
Maarten De Smet, Alessio Lissoni, Marta Pérez-Hernández   +2 more
exaly   +2 more sources

Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells

Bio-Protocol, 2021
Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels.
Joe Potter, Gareth Price, Chelsy Cliff, Bethany Williams, Claire Hills, Paul Squires   +5 more
doaj   +2 more sources

Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium

International Journal of Molecular Sciences, 2023
Previously, we reported a mechanosensitive ion channel, TRPV4, along with functional connexin hemichannels on the basolateral surface of the ocular nonpigmented ciliary epithelium (NPE).
Mohammad Shahidullah, Nicholas A Delamere   +1 more
exaly   +2 more sources

Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel

Science Advances, 2020
Cryo-EM structure of human connexin 31.3 hemichannel reveals the selective permeability mechanism. Connexin family proteins assemble into hexameric channels called hemichannels/connexons, which function as transmembrane channels or dock together to form ...
Hyuk-Joon Lee, Hyeongseop Jeong, Jae-Kyung Hyun   +2 more
exaly   +2 more sources

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

International Journal of Molecular Sciences, 2021
Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP).
Joe A Potter, Colin R Green, Paul Edward Squires   +2 more
exaly   +2 more sources

Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis. [PDF]

Nat Commun
Alzheimer’s disease (AD), the leading cause of senile dementia, lacks effective therapies. While microglia are central to AD pathology, key therapeutic targets remain unclear.
Su Y, Li H, Zhang W, Tao S, Wang Q, Zhang X, Zhou M, Huang X, Wang C, Tang Y, Chen H, Verkhratsky A, Zha Z, Niu J, Yi C.   +14 more
europepmc   +2 more sources

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage

Frontiers in Pharmacology, 2020
Background Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy.
Raghda Ramadan, Dornatien Chuo Anang, Delphine Hoorelbeke   +2 more
exaly   +2 more sources