Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
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Structure-based virtual screening for selective connexin hemichannel blockers: a historical perspective on the discovery of a small organic inhibitor [PDF]
Frontiers in PharmacologyIntroductionConnexin hemichannels are critical mediators of cellular signaling in both physiological and pathological states, yet their selective pharmacological modulation has remained elusive because of the close structural similarity between ...
Carlos F. Lagos +7 more
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Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells
Bio-Protocol, 2021 Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels.
Joe Potter +5 more
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Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode [PDF]
eLifeLoss of function mutations of Cx32, which is expressed in Schwann cells, cause X-linked Charcot-Marie-Tooth disease, a slowly progressive peripheral neuropathy.
Jack Butler +4 more
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Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis [PDF]
Frontiers in ImmunologySepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infections that is initiated by the body’s innate immune system. Nearly a decade ago, we discovered that bacterial lipopolysaccharide (LPS) and serum amyloid A (
Jianhua Li +9 more
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Bracovirus-mediated innexin hemichannel closure in cell disassembly
iScience, 2021 Summary: Cell-cell communication is necessary for cellular immune response. Hemichannel closure disrupts communication between intracellular and extracellular environments during polydnavirus-induced immunosuppression in invertebrates.
Chang-Xu Chen +11 more
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Frontiers in Chemistry, 2022 Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions), and
Sin Hang Crystal Chan +9 more
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Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]
PLoS ONE, 2013 Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez +9 more
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Scientific Reports, 2021 Mutations in five different genes encoding connexin channels cause eleven clinically defined human skin diseases. Keratitis ichthyosis deafness (KID) syndrome is caused by point mutations in the GJB2 gene encoding Connexin 26 (Cx26) which result in ...
Caterina Sellitto +2 more
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Cell Communication and Signaling, 2023 Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Elena Roger +8 more
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