Results 31 to 40 of about 5,094 (206)

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Pharmaceuticals, 2020
Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure.
Kouji Fukuyama, Yuto Ueda, Motohiro Okada   +2 more
doaj   +1 more source

Astroglial Connexins in Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2021
Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang, Yixun Su, Nan Wang, Hui Li, Zhigang Li, Guowei Yin, Hui Chen, Jianqin Niu, Chenju Yi   +8 more
doaj   +1 more source

Simulations on Simple Models of Connexin Hemichannels Indicate That Ca²⁺ Blocking Is Not a Pure Electrostatic Effect

Membranes, 2021
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between the eukariotic cell and its extracellular space.
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle   +4 more
doaj   +1 more source

Collagen I Modifies Connexin?43 Hemichannel Activity via Integrin ?2?1 Binding in TGF?1?Evoked Renal Tubular Epithelial Cells

, 2021
Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel?mediated release of adenosine triphosphate (ATP).
Claire Hills (17159905), Chelsy L Cliff (17242507), Colin R Green (17242510), Gareth Price (17165578), Paul Squires (17167891), Joe Potter (17165506)   +5 more
core   +5 more sources

Identification of a New Mutation p.P88L in Connexin 50 Associated with Dominant Congenital Cataract

Frontiers in Cell and Developmental Biology, 2022
Congenital hereditary cataract is genetically heterogeneous and the leading cause of visual impairment in children. Identification of hereditary causes is critical to genetic counselling and family planning.
Aixia Jin, Qingqing Zhao, Shuting Liu, Zi-bing Jin, Shuyan Li, Mengqing Xiang, Mingbing Zeng, Mingbing Zeng, Kangxin Jin, Kangxin Jin   +9 more
doaj   +1 more source

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity [PDF]

, 2010
Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, the molecular determinants controlling connexin-hemichannel activity are ...
Wang, Nan, Bernard Himpens, Bultynck, Geert, Catheleyne D'Hondt, De Smedt, Humbert, Vereecke, Johan, Raf Ponsaerts, Himpens, Bernard, Nan Wang, Johan Vereecke, D'hondt, Catheleyne, Retamal, Mauricio, Vermeire, Dieter, Zimmermann, Pascale, Mauricio Retamal, Geert Bultynck, Ponsaerts, Raf, Elke De Vuyst, De Vuyst, Elke, Leybaert, Luc, Pascale Zimmermann, Humbert De Smedt, D’hondt, Catheleyne, Luc Leybaert, Dieter Vermeire   +24 more
core   +1 more source

Hemichannel-mediated release of lactate [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the ...
Karagiannis, Anastassios, Sylantyev, Sergiy, Hadjihambi, Anna, Hosford, Patrick S, Kasparov, Sergey, Gourine, Alexander V   +5 more
openaire   +4 more sources

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading

eLife, 2022
Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao, Manuel A Riquelme, Teja Guda, Chao Tu, Huiyun Xu, Sumin Gu, Jean X Jiang   +6 more
doaj   +1 more source

Gap junction hemichannels in astrocytes of the CNS [PDF]

Acta Physiologica Scandinavica, 2003
AbstractConnexins are protein subunits that oligomerize into hexamers called connexons, gap junction hemichannels or just hemichannels. Because some gap junction channels are permeable to negatively and/or positively charged molecules up to ∼ 1kDa in size, it was thought that hemichannels should not open to the extracellular space.
Saez, JC, Contreras, JE, Bukauskas, FF, Retamal, MA, Bennett, MVL   +4 more
openaire   +4 more sources

Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans

Frontiers in Molecular Neuroscience, 2018
Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Francesco Zonta, Francesco Zonta, Damiano Buratto, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Andrea Carrer, Andrea Carrer, Andrea Carrer, Francesca Bruno, Guang Yang, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano, Sergio Pantano   +17 more
doaj   +1 more source