Results 31 to 40 of about 9,855 (254)
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. [PDF]
, 2016 Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma.
Abagyan, Ruben +9 more
core +13 more sources
Following Tracks of Hemichannels [PDF]
Cell Communication & Adhesion, 2003 It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel +3 more
openaire +3 more sources
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
openaire +4 more sources
Cell Communication and Signaling, 2023 Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Elena Roger +8 more
doaj +1 more source
Inhibition of astrocyte hemichannel improves recovery from spinal cord injury
JCI Insight, 2021 Spinal cord injury (SCI) causes severe disability, and the current inability to restore function to the damaged spinal cord leads to lasting detrimental consequences to patients.
Chao Zhang +14 more
semanticscholar +1 more source
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]
, 2020 Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert +10 more
core +1 more source
Connexin Hemichannel Inhibitors with a Focus on Aminoglycosides.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021 Connexins are membrane proteins involved directly in cell-to-cell communication through the formation of gap-junctional channels. These channels result from the head-to-head docking of two hemichannels, one from each of two adjacent cells.
C. Natha +4 more
semanticscholar +1 more source
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these connexins can all induce hemichannel currents, but other lens proteins (e.g., pannexin1) can also induce ...
Beyer, Eric C., Berthoud, Viviana M.
openaire +3 more sources
Cell Communication and Signaling, 2020 Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate
Gareth W. Price +9 more
semanticscholar +1 more source
Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
bioRxiv, 2021 Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. While most of these disease-linked variants cause loss-of-function due to misfolding or aberrant trafficking, others directly alter channel properties ...
Jun-Jie Tong +7 more
semanticscholar +1 more source