Results 31 to 40 of about 4,743 (216)

4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation [PDF]

, 2020
Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open ...
Peña, Francisca, Quintana, Daisy, Altenberg, Guillermo A., Stehberg, Jimmy, Fernández-Olivares, Ainoa, Fiori, Mariana C., Linsambarth, Sergio, Retamal, Mauricio   +7 more
core   +1 more source

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity [PDF]

, 2010
Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, the molecular determinants controlling connexin-hemichannel activity are ...
Wang, Nan, Bernard Himpens, Bultynck, Geert, Catheleyne D'Hondt, De Smedt, Humbert, Vereecke, Johan, Raf Ponsaerts, Himpens, Bernard, Nan Wang, Johan Vereecke, D'hondt, Catheleyne, Retamal, Mauricio, Vermeire, Dieter, Zimmermann, Pascale, Mauricio Retamal, Geert Bultynck, Ponsaerts, Raf, Elke De Vuyst, De Vuyst, Elke, Leybaert, Luc, Pascale Zimmermann, Humbert De Smedt, D’hondt, Catheleyne, Luc Leybaert, Dieter Vermeire   +24 more
core   +2 more sources

Simulations on Simple Models of Connexin Hemichannels Indicate That Ca²⁺ Blocking Is Not a Pure Electrostatic Effect

Membranes, 2021
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between the eukariotic cell and its extracellular space.
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle   +4 more
doaj   +1 more source

Identification of a New Mutation p.P88L in Connexin 50 Associated with Dominant Congenital Cataract

Frontiers in Cell and Developmental Biology, 2022
Congenital hereditary cataract is genetically heterogeneous and the leading cause of visual impairment in children. Identification of hereditary causes is critical to genetic counselling and family planning.
Aixia Jin, Qingqing Zhao, Shuting Liu, Zi-bing Jin, Shuyan Li, Mengqing Xiang, Mingbing Zeng, Mingbing Zeng, Kangxin Jin, Kangxin Jin   +9 more
doaj   +1 more source

Hemichannel-mediated release of lactate [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the ...
Karagiannis, Anastassios, Sylantyev, Sergiy, Hadjihambi, Anna, Hosford, Patrick S, Kasparov, Sergey, Gourine, Alexander V   +5 more
openaire   +4 more sources

The Role of Connexin Hemichannels in Inflammatory Diseases [PDF]

Biology, 2022
The connexin protein family consists of approximately 20 members, and is well recognized as the structural unit of the gap junction channels that perforate the plasma membranes of coupled cells and, thereby, mediate intercellular communication. Gap junctions are assembled by two preexisting hemichannels on the membranes of apposing cells.
Bo Peng, Chengping Xu, Shuaiwei Wang, Yijie Zhang, Wei Li   +4 more
openaire   +3 more sources

Tonabersat breaks the cycle of Cx43- hemichannel mediated activity and NLRP3 inflammasome activation in a model of diabetic nephropathy [PDF]

, 2023
Introduction: Our previous findings link connexin-43 (Cx43)-hemichannel mediated ATP release to an increase in the nod-like receptor protein-3 (NLRP3) inflammasome, via nuclear factor kappa-B (NF?B)-mediated priming and purinergic P2X7 receptor (P2X7R ...
Claire Hills (17159905), CL Cliff (17932166), Bethany Williams (17170132), Paul Squires (17167891)   +3 more
core   +2 more sources

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading

eLife, 2022
Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao, Manuel A Riquelme, Teja Guda, Chao Tu, Huiyun Xu, Sumin Gu, Jean X Jiang   +6 more
doaj   +1 more source

Gap junction hemichannels in astrocytes of the CNS [PDF]

Acta Physiologica Scandinavica, 2003
AbstractConnexins are protein subunits that oligomerize into hexamers called connexons, gap junction hemichannels or just hemichannels. Because some gap junction channels are permeable to negatively and/or positively charged molecules up to ∼ 1kDa in size, it was thought that hemichannels should not open to the extracellular space.
Saez, JC, Contreras, JE, Bukauskas, FF, Retamal, MA, Bennett, MVL   +4 more
openaire   +4 more sources

Induction of Connexin-hemichannel Opening [PDF]

, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Sansonetti, Philippe, Puhar, Andrea; id_orcid, Puhar, Andrea,, Sansonetti, Philippe J.,   +3 more
core   +1 more source