Results 1 to 10 of about 43,790 (245)

Modulation of connexin 43 in viral infections [PDF]

Tumour Virus Research
Connexins are essential for intercellular communication through gap junctions and the maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most ubiquitously expressed connexin. As well as regulating homeostasis, Cx43 hemichannels and
Harry Scott, Patricia E. Martin, Sheila V. Graham   +2 more
doaj   +5 more sources

Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue [PDF]

Reproductive Biology and Endocrinology, 2006
Background Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium.
Malmström Anders, Cebers Gvido, Dahlqvist Camilla, Klimaviciute Aurelija, Byström Birgitta, Cluff Ann, Ekman-Ordeberg Gunvor   +6 more
doaj   +3 more sources

Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells [PDF]

Reproductive Biology and Endocrinology, 2008
Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons, Roskams Tania, Deprest Jan, Gevaert Thomas, Hutchings Graham, Nilius Bernd, De Ridder Dirk   +6 more
doaj   +3 more sources

Connexin 43 confers chemoresistance through activating PI3K [PDF]

Oncogenesis, 2022
Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is difficult ...
Kevin J. Pridham, Farah Shah, Kasen R. Hutchings, Kevin L. Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina L. Grek, Gautam G. Ghatnekar, Robin Varghese, Deborah F. Kelly, Robert G. Gourdie, Zhi Sheng   +16 more
doaj   +4 more sources

Connexin 43 impacts on mitochondrial potassium uptake [PDF]

Frontiers in Pharmacology, 2013
In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria.
Kerstin eBoengler, Elvira eUngefug, Gerd eHeusch, Luc eLeybaert, Rainer eSchulz   +4 more
doaj   +4 more sources

Connexin 43 Phosphorylation: Implications in Multiple Diseases

Molecules, 2023
Connexin 43 (Cx43) is most widely distributed in mammals, especially in the cardiovascular and nervous systems. Its phosphorylation state has been found to be regulated by the action of more than ten kinases and phosphatases, including mitogen-activated ...
Meng Zhang, Zhen-Zhen Wang, Nai-Hong Chen   +2 more
doaj   +3 more sources

Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype [PDF]

Brain Sciences, 2018
Astrocytes are the most abundant glial cells of the central nervous system and have recently been recognized as crucial in the regulation of brain immunity.
Anne-Cécile Boulay, Alice Gilbert, Vanessa Oliveira Moreira, Corinne Blugeon, Sandrine Perrin, Juliette Pouch, Stéphane Le Crom, Bertrand Ducos, Martine Cohen-Salmon   +8 more
doaj   +3 more sources

Research progress of connexin 43 in cardiovascular diseases [PDF]

Frontiers in Cardiovascular Medicine
Gap junctions (GJs) are critical structures for cardiac electrical signal conduction and synchronized contraction. Their fundamental components are transmembrane proteins from the connexin (Cx) family, which assemble into hexameric channels to form ...
Zhao Xinxin, Han Pan, Li Qiao
doaj   +2 more sources

Connexin 43 hemichannels and related diseases. [PDF]

Antib Ther
Abstract Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liver, hemichannels are found in specific cell types, such as astrocytes and osteocytes. They
Zhang Y, Acosta FM, Jiang JX.
europepmc   +3 more sources

Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation

Frontiers in Cell and Developmental Biology, 2022
Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
doaj   +3 more sources