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Function of Connexin-43 in Macrophages [PDF]
International Journal of Molecular Sciences, 2020 Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory ...
Daniel Rodjakovic +2 more
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The Role of Connexin 43 in Lung Disease [PDF]
Life, 2020 The term lung disease describes a broad category of disorders that impair lung function. More than 35 million Americans have a preventable chronic lung disease with high mortality rates due to limited treatment efficacy.
Julie A. Swartzendruber +2 more
doaj +3 more sources
Connexin 43 impacts on mitochondrial potassium uptake [PDF]
Frontiers in Pharmacology, 2013 In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria.
Kerstin eBoengler +4 more
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Modulation of connexin 43 in viral infections
Tumour Virus ResearchConnexins are essential for intercellular communication through gap junctions and the maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most ubiquitously expressed connexin. As well as regulating homeostasis, Cx43 hemichannels and
Harry Scott +2 more
doaj +4 more sources
Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype [PDF]
Brain Sciences, 2018 Astrocytes are the most abundant glial cells of the central nervous system and have recently been recognized as crucial in the regulation of brain immunity.
Anne-Cécile Boulay +8 more
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Biomedicines, 2023 Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. Although its pathogenesis is not fully understood, connexins (Cxs) and pannexins (Panx) could be involved in the process of fibrosis. We analyzed
Dubravka Vukovic +2 more
exaly +3 more sources
Research progress of connexin 43 in cardiovascular diseases
Frontiers in Cardiovascular MedicineGap junctions (GJs) are critical structures for cardiac electrical signal conduction and synchronized contraction. Their fundamental components are transmembrane proteins from the connexin (Cx) family, which assemble into hexameric channels to form ...
Zhao Xinxin, Han Pan, Li Qiao
doaj +3 more sources
Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa
Physiological ReportsThe zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis.
Gabriel Stölting +6 more
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Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis [PDF]
Medicinski Podmladak, 2022 Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation.
Savić Ivana +2 more
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Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
Basic and Clinical Neuroscience, 2014 Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS).
Hossein Mostafavi +8 more
doaj +2 more sources