Results 21 to 30 of about 43,790 (245)
Frontiers in Oncology, 2020 Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang +7 more
doaj +1 more source
Cardiac mitochondrial connexin 43 regulates apoptosis [PDF]
Biochemical and Biophysical Research Communications, 2007 Connexin 43 (Cx43) is thought to be present largely in the plasma membrane and its function solely to provide low resistance electrical connection between myocytes. A recent report suggested the presence of Cx43 in the mitochondria as well. We confirmed the presence of Cx43 in the mitochondria isolated from adult rat ventricles with the Cx43 ...
Farida, Goubaeva +5 more
openaire +2 more sources
Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study [PDF]
PeerJ, 2022 Background Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood.
Ivana Savic +4 more
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Postępy Higieny i Medycyny Doświadczalnej, 2020 Skeleton formation and its proper functioning is possible thanks to specialized bone tissue cells: bone forming osteoblasts, bone resorbing osteoclasts and osteocytes located in bone cavities. Gap junctions are transmembrane channels connecting neighboring cell. Thanks to gap junctions it is possible for signals to be directly transmitted by cells. Gap
Krzysztof Łukowicz +3 more
openaire +1 more source
Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder [PDF]
International Neurourology Journal, 2011 Purpose Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.
Sung Ho Song +5 more
doaj +1 more source
Connexin-dependent neuroglial networking as a new therapeutic target [PDF]
, 2017 Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks.
Christian C. Naus +5 more
core +5 more sources
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]
, 2020 Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert +10 more
core +1 more source
Connexin communication compartments and wound repair in epithelial tissue [PDF]
, 2018 Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc +4 more
core +9 more sources
Folia Histochemica et Cytobiologica, 2008 The interaction of connexin 43 and E-cadherin may play an important role in carcinogenesis and malignant behaviour of tumours. In this study, we examined the relationship between connexin 43 and E-cadherin in human non-small cell lung cancers (NSCLC ...
En-Hua Wang +6 more
doaj +1 more source
Diet-dependent immunohistochemical evaluation of connexin 43 in the sheep rumen [PDF]
, 2016 The objective of this study was to characterize the immunohistochemical localization of plasma membrane connexin 43 in the rumen of sheep after changing the diet from hay (ad libitum) to a mixed hay/concentrate diet.
Ahmed, Rasha S. +2 more
core +1 more source