Results 21 to 30 of about 1,371,072 (142)
Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder [PDF]
International Neurourology Journal, 2011 Purpose Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.
Sung Ho Song +5 more
doaj +1 more source
Connexin 43 Phosphorylation: Implications in Multiple Diseases
Molecules, 2023 Connexin 43 (Cx43) is most widely distributed in mammals, especially in the cardiovascular and nervous systems. Its phosphorylation state has been found to be regulated by the action of more than ten kinases and phosphatases, including mitogen-activated ...
Meng Zhang +2 more
doaj +1 more source
Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study [PDF]
PeerJ, 2022 Background Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood.
Ivana Savic +4 more
doaj +2 more sources
Connexin 43 confers chemoresistance through activating PI3K
Oncogenesis, 2022 Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is difficult ...
Kevin J. Pridham +16 more
doaj +1 more source
Dynamic changes in connexin expression correlate with key events in the wound healing process. [PDF]
, 2003 Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of
Kamaldeep Tamber +9 more
core +1 more source
, 2022 This is supplementary material of the manuscript entitled: Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice.
Lai-hua Xie (12361865) +10 more
core +1 more source
Connexin 43 Hemichannels Are Permeable to ATP [PDF]
The Journal of Neuroscience, 2008 Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang +6 more
openaire +2 more sources
Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Frontiers in Cell and Developmental Biology, 2022 Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
doaj +1 more source
Internal translation of the connexin 43 transcript [PDF]
Cell Communication and Signaling, 2014 Connexin 43 (Cx43), the most widely expressed gap junction protein, is associated with a number of physiological and pathological conditions. Many functions of Cx43 have been shown to be independent of gap junction formation and only require the expression of Cx43 C-terminal fragments.
Salat-Canela, Clàudia +4 more
openaire +3 more sources
BMC Medicine, 2008 Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N +5 more
doaj +1 more source