Results 11 to 20 of about 1,371,072 (142)
Connexin-43-dependent ATP release mediates macrophage activation during sepsis [PDF]
eLife, 2019 Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Michel Dosch +7 more
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Connexin 43 recruits E-cadherin expression and inhibits the malignant behaviour of lung cancer cells. [PDF]
Folia Histochemica et Cytobiologica, 2008 The interaction of connexin 43 and E-cadherin may play an important role in carcinogenesis and malignant behaviour of tumours. In this study, we examined the relationship between connexin 43 and E-cadherin in human non-small cell lung cancers (NSCLC ...
En-Hua Wang +6 more
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Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells [PDF]
Reproductive Biology and Endocrinology, 2008 Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons +6 more
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Connexin 43 signalling and cardioprotection [PDF]
Heart, 2005 Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.
K, Boengler, R, Schulz, G, Heusch
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Connexin 26 and Connexin 43 in Canine Mammary Carcinoma [PDF]
Veterinary Sciences, 2019 Incidence of canine mammary carcinoma is two times higher than the rate of human breast cancer. Mammary tumors are the most common type of cancer in intact female dogs and account for about half of all neoplasms in these dogs. Well-established models of breast cancer have shown that neoplastic cells often have a loss of intercellular communication ...
Savannah Luu +3 more
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HPV-16 E6, hDlg and Connexin 43 in cervical carcinogenesis [PDF]
, 2005 Disruption of gap junctional intercellular communication and/or Connexins (the channel proteins of gap junctions) is frequently reported in malignant cell lines and tumours.
Sun, Peng
core +8 more sources
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. [PDF]
PLoS ONE, 2011 Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular
Yue Zhang +8 more
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Identification of Connexin-43 Interacting Proteins [PDF]
Cell Communication & Adhesion, 2003 Connexin-43 (Cx43), the most ubiquitously expressed vertebrate gap junction protein, has been shown to interact directly with Zonula Occludens-1 (ZO-1). Although several potential functions have been proposed for the ZO-1/Cx43 interaction, the role that ZO-1 and other Cx43-interacting partners play in the regulation of Cx43 trafficking, assembly ...
Deepika, Singh, Paul D, Lampe
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Frontiers in Oncology, 2020 Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang +7 more
doaj +1 more source
Postępy Higieny i Medycyny Doświadczalnej, 2020 Skeleton formation and its proper functioning is possible thanks to specialized bone tissue cells: bone forming osteoblasts, bone resorbing osteoclasts and osteocytes located in bone cavities. Gap junctions are transmembrane channels connecting neighboring cell. Thanks to gap junctions it is possible for signals to be directly transmitted by cells. Gap
Krzysztof Łukowicz +3 more
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