“Homicide and Zonisamide”: a review of the literature and illustrative case report on second and third generation antiseizure medications and psychiatric effects [PDF]
Frontiers in PsychiatryIntroductionCerebral cavernous malformations (CCMs) are vascular lesions that can cause focal epilepsy due to local hemosiderin deposition, gliosis, and cortical irritation.
Stefanie Nguyen +3 more
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Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by Acanthamoeba castellanii and Naegleria Fowleri [PDF]
Parasite Epidemiology and ControlAcanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Devandran Apparasamy +8 more
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Phase II pilot randomized trial of zonisamide for disease modification in prodromal Lewy body disease [PDF]
npj Parkinson's DiseaseZonisamide exhibits potential neuroprotective properties, but its efficacy during the prodromal stage of Lewy body disease (LBD) remains unclear. In this phase II randomized, double-blind pilot trial, 29 high-risk individuals aged 50–80 years with ≥2 ...
Keita Hiraga +20 more
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Veterinary Medicine and Science, 2022 A 3‐year‐old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine.
Takamasa Itoi +7 more
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Journal of Veterinary Internal Medicine, 2022 Background Acute hepatopathy secondary to administration of zonisamide has been reported in 2 dogs, but overall incidence of hepatopathy is unknown. Objective To characterize the incidence of hepatopathy in dogs administered zonisamide PO.
Tess K. Smith +2 more
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Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. [PDF]
PLoS ONE, 2015 No clinically applicable drug is currently available to enhance neurite elongation after nerve injury. To identify a clinically applicable drug, we screened pre-approved drugs for neurite elongation in the motor neuron-like NSC34 cells.
Hideki Yagi +11 more
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Zonisamide Ameliorates Microglial Mitochondriopathy in Parkinson’s Disease Models
Brain Sciences, 2022 Mitochondrial dysfunction and exacerbated neuroinflammation are critical factors in the pathogenesis of both familial and non-familial forms of Parkinson’s disease (PD).
Satoshi Tada +5 more
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Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
Frontiers in Veterinary Science, 2021 Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes.
Shinichi Kanazono +4 more
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Limited efficacy of zonisamide in the treatment of refractory infantile spasms
Epilepsia Open, 2020 A series of relatively small studies collectively suggest that zonisamide may be effective in the treatment of infantile spasms. Using a large single‐center cohort of children with infantile spasms, we set out to evaluate the efficacy and safety of ...
Shaun A. Hussain +7 more
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Intraoperative acidosis related to chronic zonisamide therapy. [PDF]
Pediatric Anesthesia and Critical Care Journal (PACCJ), 2021 Zonisamide is a novel anticonvulsant agent used in the treatment of partial and generalized seizures in children and adults. In addition to its anticonvulsant effects, zonisamide inhibits carbonic anhydrase and may result in a chronic, non-anion gap ...
A. G. Mohr +4 more
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