Results 21 to 30 of about 12,742 (223)

Design of Novel Drugs (P3TZ, H2P3TZ, M2P3TZ, H4P3TZ and M4P3TZ) Based on Zonisamide for Autism Treatment by Binding to Potassium Voltage-gated Channel Subfamily D Member 2 (Kv4.2) [PDF]

International Journal of New Chemistry, 2019
The present research article relates to the discovery of the novel drugs based on Zonisamide to treatment of autism disease. In first step, the electronic properties, reactivity and stability of the said compound are discussed. To attain these properties,
Mehdi Nabati, Vida Bodaghi-Namileh
doaj   +1 more source

Zonisamide Suppresses Pain Symptoms of Formalin-Induced Inflammatory and Streptozotocin-Induced Diabetic Neuropathy

Journal of Pharmacological Sciences, 2008
We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced withdrawal threshold to mechanical stimuli, respectively.
Mitsuo Tanabe, Takuhiro Murakami, Hideki Ono   +2 more
doaj   +1 more source

Botulinum toxin type A for Holmes tremor secondary to thalamic hemorrhage [PDF]

, 2015
Holmes tremor (HT) is a low-frequency rest and intentional tremor frequently affecting the upper limb.
Giovannelli, Morena, Latino, Pamela, Orzi, Francesco, Pontieri, FRANCESCO ERNESTO   +3 more
core   +1 more source

The Supraspinally Mediated Analgesic Effects of Zonisamide in Mice After Peripheral Nerve Injury Are Independent of the Descending Monoaminergic System

Journal of Pharmacological Sciences, 2007
We have previously demonstrated that the antiepileptic drug zonisamide supraspinally generates analgesic effects on thermal and mechanical hypersensitivity in mice after peripheral nerve injury.
Mitsuo Tanabe, Yuichi Takeuchi, Hideki Ono   +2 more
doaj   +1 more source

Newer drugs for focal epilepsy in adults [PDF]

, 2012
A 28 year old woman sees her general practitioner after experiencing what sounds like a convulsion without any apparent provoking factor. Over the past month she has also had “blank spells” during which her husband noticed her to be unresponsive.
Brodie, M., Kwan, P.
core   +1 more source

Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP

Journal of Pharmacological Sciences, 2009
.: The effect of zonisamide, an antiepileptic agent with anti-parkinsonian effects, was studied on dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 mice and common marmosets. Groups of mice (n = 8 – 9) were treated with:
Hayato Yabe, Mohammed Emamussalehin Choudhury, Madoka Kubo, Noriko Nishikawa, Masahiro Nagai, Masahiro Nomoto   +5 more
doaj   +1 more source

Zonisamide improves axial symptoms in dementia with Lewy bodies with parkinsonism: Post hoc analysis of clinical trials

eNeurologicalSci, 2022
Patients with dementia with Lewy bodies (DLB) experience worsening axial symptoms with disease progression, which can negatively affect quality of life.
Yoshio Tsuboi, Kenji Kochi, Hidenori Maruyama, Yuji Matsumoto   +3 more
doaj   +1 more source

Zonisamide, Topiramate, and Levetiracetam: Efficacy and Neuropsychological Effects in Alcohol Use Disorders [PDF]

, 2015
The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment.
Ciraulo, Domenic A., Colaneri, Laurie, Devine, Eric, Knapp, Clifford M., Oscar-Berman, Marlene, Putnam, Meghan, Richambault, Courtney, Richardson, Mark A., Sarid-Segal, Ofra, Streeter, Chris C., Surprise, Caitlin, Waters, Megan   +11 more
core   +1 more source

The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data

Drug Design, Development and Therapy, 2021
Babak Tousi,1,2 James B Leverenz2 1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; 2Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USACorrespondence: Babak TousiLou Ruvo Center for ...
Tousi B, Leverenz JB
doaj  

Comparison of the Effects of Zonisamide and Flupirtine on Paclitaxel Induced Peripheral Neuropathy in Rats [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Many peripheral and central causes lead to neuropathic pain disorders. Effective treatment of neuropathic pain is not completely manageable and hence, it becomes necessary to evaluate the application of Zonisamide as a sodium channel and T ...
Bhuvaneswari Krishnamurthy, Prashanth Ashok Kumar, Abilash Sathyanarayanan   +2 more
doaj   +1 more source