Results 41 to 50 of about 5,094 (206)
Connexin hemichannel and pannexin channel electrophysiology: How do they differ? [PDF]
, 2014 Connexin hemichannels are postulated to form a cell permeabilization pore for the uptake of fluorescent dyes and release of cellular ATP. Connexin hemichannel activity is enhanced by low external [Ca2+]o, membrane depolarization, metabolic inhibition ...
Zhang, Xian +2 more
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Cells, 2023 In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells that attack the central nervous system (CNS), which causes and sustains neuroinflammation.
Katarina D. Milicevic +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness, where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis Deafness (KID) syndrome.
Ana C. Abbott +17 more
doaj +1 more source
The role of pannexin hemichannels in inflammation and regeneration [PDF]
Frontiers in Physiology, 2014 Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue inflammation and regeneration. The inflammatory response is an important prerequisite for regeneration.
Helen P. Makarenkova +2 more
openaire +3 more sources
Connexin 43 in Mitochondria: What Do We Really Know About Its Function?
Frontiers in Physiology, 2022 Connexins are known for their ability to mediate cell-cell communication via gap junctions and also form hemichannels that pass ions and molecules over the plasma membrane when open.
Kerstin Boengler +3 more
doaj +1 more source
Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj +1 more source
Hemichannel openings due to dephosphorylation.
, 2012 (A) After adding 10 units of CIP to the chamber, Cx43 hemichannel mediated increases in conductance were observed. (B) CIP did not cause increases in conductance when Cx43 proteoliposomes that were previously dephosphorylated using CIP, were fused to the
Carlo Montemagno (125840) +3 more
core +1 more source
Connexin hemichannels and cochlear function [PDF]
Neuroscience Letters, 2019 Connexins play vital roles in hearing, including promoting cochlear development and sustaining auditory function in the mature cochlea. Mutations in connexins expressed in the cochlear epithelium, Cx26 and Cx30, cause sensorineural deafness and in the case of Cx26, is one of the most common causes of non-syndromic, hereditary deafness.
openaire +2 more sources
Connexin 43 Hemichannels Are Permeable to ATP [PDF]
The Journal of Neuroscience, 2008 Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang +6 more
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Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]
Journal of Insect Science, 2011 Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
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