Results 41 to 50 of about 4,743 (216)

Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans

Frontiers in Molecular Neuroscience, 2018
Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Francesco Zonta, Francesco Zonta, Damiano Buratto, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Andrea Carrer, Andrea Carrer, Andrea Carrer, Francesca Bruno, Guang Yang, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano, Sergio Pantano   +17 more
doaj   +1 more source

image_2_Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function.jpeg [PDF]

, 2018
The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Victoria Velarde (5632436), Beatriz C. Avendaño (5632427), Juan C. Sáez (446103), Rosario Gajardo-Gómez (5632424), Esteban F. Díaz (5632430), Susana Contreras-Duarte (4436662), Juan A. Orellana (446097), Cristian A. Santibañez (5632421), Trinidad D. Montero (5632433), Gonzalo I. Gómez (5632415), Valeria C. Labra (5632418)   +10 more
core   +1 more source

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability [PDF]

, 2021
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of ...
Lissoni, A., Wang, N., Dries, E., Witschas, K., De Smet, Maarten A.J., Wang, Nan, Rothenberg, Eli, Bultynck, Geert, Schulz, R., Dries, Eef, Delmar, Mario, Lin, X., Nezlobinsky, T., Amoni, Matthew, Leybaert, L., Rothenberg, E., Perez-Hernandez, Marta, Panfilov, Alexander V., Panfilov, A. V., Delmar, M., Nezlobinsky, Timur, Nezlobinskii, Timur, Bultynck, G., Vervliet, T., Lin, Xianming, Sipido, Karin R., Vervliet, Tim, Sipido, K. R., Schulz, Rainer, Witschas, Katja, Leybaert, Luc, Amoni, M., De Smet, Maarten, Panfilov, Alexander, Lissoni, Alessio, Pérez-Hernández, M., de, Smet, M. A. J.   +36 more
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The role of pannexin hemichannels in inflammation and regeneration [PDF]

Frontiers in Physiology, 2014
Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue inflammation and regeneration. The inflammatory response is an important prerequisite for regeneration.
Helen P. Makarenkova, Valery I. Shestopalov, Valery I. Shestopalov   +2 more
openaire   +3 more sources

Non-additive effects of delayed connexin hemichannel blockade and hypothermia after cerebral ischemia in near-term fetal sheep [PDF]

, 2015
Hypothermia is partially neuroprotective after neonatal hypoxic-ischemic encephalopathy. Blockade of connexin hemichannels can improve recovery of brain activity and cell survival after ischemia in near-term fetal sheep.
Green, Colin, Rout, AL, Wassink, Guido, Bennet, Laura, Yuill, CA, Zhang, FG, Davidson, Joanne, Gunn, Alistair   +7 more
core   +1 more source

Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel [PDF]

, 2020
Connexin family proteins assemble into hexameric channels called hemichannels/connexons, which function as transmembrane channels or dock together to form gap junction intercellular channels (GJIChs). We determined the cryo-electron microscopy structures
Ryu, Bumhan, Lim, Hyun-Ho, Park, Kunwoong, Jeong, Hyeongseop, Yoo, Jejoong, Woo, Jae-Sung, Hyun, Jaekyung, Lee, Hyuk-Joon   +7 more
core   +2 more sources

Astroglial Cell-to-Cell Interaction with Autoreactive Immune Cells in Experimental Autoimmune Encephalomyelitis Involves P2X7 Receptor, β₃-Integrin, and Connexin-43

Cells, 2023
In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells that attack the central nervous system (CNS), which causes and sustains neuroinflammation.
Katarina D. Milicevic, Danijela B. Bataveljic, Jelena J. Bogdanovic Pristov, Pavle R. Andjus, Ljiljana M. Nikolic   +4 more
doaj   +1 more source

Hemichannel blockers in an artificial bilayer environment. [PDF]

, 2012
(A) The addition of Heptanol to conducting Cx43 hemichannels terminated ionic current. (B) The addition of Carbenoxolone had no effect on open Cx43 hemichannels.
Carlo Montemagno (125840), Jacob Todd (125838), David Wendell (125842), Cole Brokamp (125837)   +3 more
core   +1 more source

Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti

Frontiers in Cell and Developmental Biology, 2023
Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness, where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis Deafness (KID) syndrome.
Ana C. Abbott, Ana C. Abbott, Isaac E. García, Isaac E. García, Isaac E. García, Felipe Villanelo, Felipe Villanelo, Carolina Flores-Muñoz, Ricardo Ceriani, Ricardo Ceriani, Jaime Maripillán, Joel Novoa-Molina, Cindel Figueroa-Cares, Tomas Pérez-Acle, Tomas Pérez-Acle, Juan C. Sáez, Helmuth A. Sánchez, Agustín D. Martínez   +17 more
doaj   +1 more source

Connexin hemichannels and cochlear function [PDF]

Neuroscience Letters, 2019
Connexins play vital roles in hearing, including promoting cochlear development and sustaining auditory function in the mature cochlea. Mutations in connexins expressed in the cochlear epithelium, Cx26 and Cx30, cause sensorineural deafness and in the case of Cx26, is one of the most common causes of non-syndromic, hereditary deafness.
openaire   +2 more sources