Results 41 to 50 of about 9,855 (254)
The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems [PDF]
, 2018 In the epidermis, remodelling of Connexin43 is a key event in wound closure. However, controversy between the role of connexin channel and non-channel functions exist.
Annette Graham +7 more
core +9 more sources
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. [PDF]
PLoS ONE, 2012 Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive.
Jingwei Chi +7 more
doaj +1 more source
Cells, 2023 In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells that attack the central nervous system (CNS), which causes and sustains neuroinflammation.
Katarina D. Milicevic +4 more
doaj +1 more source
Adhesive properties of connexin hemichannels [PDF]
Glia, 2008 AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
openaire +2 more sources
Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
The Journal of Clinical Investigation, 2023 Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness, where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis Deafness (KID) syndrome.
Ana C. Abbott +17 more
doaj +1 more source
Hemichannel-mediated release of lactate [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2015 In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the membranes.
Karagiannis, Anastassios +5 more
openaire +6 more sources
Pharmaceuticals, 2020 Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure.
Kouji Fukuyama +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 This study was undertaken to evaluate the connexin hemichannel blocker tonabersat for the inhibition of inflammasome activation and use as a potential treatment for diabetic retinopathy.
Heather Lyon +4 more
semanticscholar +1 more source
Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources