Results 61 to 70 of about 9,855 (254)
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]
, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Bultynck, Geert +4 more
core +2 more sources
Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity? [PDF]
, 2017 Indexación: Scopus.In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons.
Alcayaga, J. +3 more
core +1 more source
Identification of a New Mutation p.P88L in Connexin 50 Associated with Dominant Congenital Cataract
Frontiers in Cell and Developmental Biology, 2022 Congenital hereditary cataract is genetically heterogeneous and the leading cause of visual impairment in children. Identification of hereditary causes is critical to genetic counselling and family planning.
Aixia Jin +9 more
doaj +1 more source
Connexin hemichannels and cochlear function [PDF]
Neuroscience Letters, 2019 Connexins play vital roles in hearing, including promoting cochlear development and sustaining auditory function in the mature cochlea. Mutations in connexins expressed in the cochlear epithelium, Cx26 and Cx30, cause sensorineural deafness and in the case of Cx26, is one of the most common causes of non-syndromic, hereditary deafness.
openaire +2 more sources
Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj +1 more source
Pharmaceuticals, 2020 To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular ...
Kouji Fukuyama +3 more
doaj +1 more source
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
eLife, 2022 Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao +6 more
doaj +1 more source
Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke [PDF]
, 2019 Connexin43 (Cx43) function is influenced by kinases that phosphorylate specific serine sites located near its C-terminus. Stroke is a powerful inducer of kinase activity, but its effect on Cx43 is unknown. We investigated the impact of wild-type (WT) and
Bechberger, John F +6 more
core +2 more sources
Connexins in Lung Cancer and Brain Metastasis
Frontiers in Oncology, 2020 Connexins (Cxs) are involved in the brain metastasis of lung cancer cells. Thus, it is necessary to determine whether gap junction-forming Cxs are involved in the communication between lung cancer cells and the host cells, such as endothelial cells ...
Kai-Jun Luo +9 more
doaj +1 more source
Biology Open, 2015 Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass +3 more
doaj +1 more source