Results 71 to 80 of about 4,743 (216)

Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes

Glia, Volume 74, Issue 9, September 2026.
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani, Kabeer Abubakar, Tin Luka Petanjek, Monique Esclapez, Anton Ivanov, Christophe Bernard   +5 more
wiley   +1 more source

Hemichannels: new roles in astroglial function

Frontiers in Physiology, 2014
The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
doaj   +1 more source

Structure of the connexin-43 gap junction channel in a putative closed state

eLife, 2023
Gap junction channels (GJCs) mediate intercellular communication by connecting two neighbouring cells and enabling direct exchange of ions and small molecules.
Chao Qi, Silvia Acosta Gutierrez, Pia Lavriha, Alaa Othman, Diego Lopez-Pigozzi, Erva Bayraktar, Dina Schuster, Paola Picotti, Nicola Zamboni, Mario Bortolozzi, Francesco Luigi Gervasio, Volodymyr M Korkhov   +11 more
doaj   +1 more source

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Regulation of Connexin Hemichannels by Monovalent Cations [PDF]

The Journal of General Physiology, 2005
Opening of connexin hemichannels in the plasma membrane is highly regulated. Generally, depolarization and reduced extracellular Ca2+ promote hemichannel opening. Here we show that hemichannels formed of Cx50, a principal lens connexin, exhibit a novel form of regulation characterized by extraordinary sensitivity to extracellular monovalent cations ...
Srinivas, Miduturu, Calderon, D. Paola, Kronengold, Jack, Verselis, Vytas K.   +3 more
openaire   +2 more sources

The Role of Connexin 43 and Pannexin 1 During Acute Inflammation

Frontiers in Physiology, 2020
During acute inflammation, the recruitment of leukocytes from the blood stream into the inflamed tissue is a well-described mechanism encompassing the interaction of endothelial cells with leukocytes allowing leukocytes to reach the site of tissue injury
Petra Kameritsch, Petra Kameritsch, Kristin Pogoda   +2 more
doaj   +1 more source

Connexin Gap Junctions and Hemichannels in Modulating Lens Redox Homeostasis and Oxidative Stress in Cataractogenesis

Antioxidants, 2021
The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan, Yu Du, Yuxin Tong, Sumin Gu, Jean X. Jiang   +4 more
doaj   +1 more source

Membrane‐Associated Biomolecules for Synthetic Cell Signalling

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack, Bingkun Li, Charlie Newell, Michael J. Booth   +3 more
wiley   +1 more source

Voltage-dependent facilitation of Cx46 hemichannels

American Journal of Physiology-Cell Physiology, 2010
Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Structure-based virtual screening for selective connexin hemichannel blockers: a historical perspective on the discovery of a small organic inhibitor

Frontiers in Pharmacology
IntroductionConnexin hemichannels are critical mediators of cellular signaling in both physiological and pathological states, yet their selective pharmacological modulation has remained elusive because of the close structural similarity between ...
Carlos F. Lagos, Carlos F. Lagos, Anibal Vargas, Anibal García, Yorley Duarte, Chenju Yi, Chenju Yi, Juan C. Sáez   +7 more
doaj   +1 more source