Results 71 to 80 of about 5,094 (206)
Structure of the connexin-43 gap junction channel in a putative closed state
eLife, 2023 Gap junction channels (GJCs) mediate intercellular communication by connecting two neighbouring cells and enabling direct exchange of ions and small molecules.
Chao Qi +11 more
doaj +1 more source
Connexin and pannexin hemichannels of neurons and astrocytes [PDF]
Channels, 2008 Hemichannels are large pore ion channels that in the traditional view are formed when half a gap connexin junction opens to the extracellular space. It is now evident that other ion channel families, including the newly discovered pannexin family can form channels with all the nascent properties of hemichannels.
Roger J, Thompson, Brian A, Macvicar
openaire +2 more sources
Antioxidants, 2021 The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source
Pharmaceuticals, 2020 To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular ...
Kouji Fukuyama +3 more
doaj +1 more source
Pharmaceuticals, 2021 Accumulating neuropsychopharmacological evidence has suggested that functional abnormalities of astroglial transmission and protein kinase B (Akt) contribute to the pathophysiology and/or pathomechanisms of several neuropsychiatric disorders, such as ...
Kouji Fukuyama, Motohiro Okada
doaj +1 more source
Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes
Glia, Volume 74, Issue 9, September 2026.Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani +5 more
wiley +1 more source
, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Victoria Velarde (5632436) +10 more
core +1 more source
Voltage-dependent facilitation of Cx46 hemichannels
American Journal of Physiology-Cell Physiology, 2010 Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A. +3 more
openaire +5 more sources
Connexins in Lung Cancer and Brain Metastasis
Frontiers in Oncology, 2020 Connexins (Cxs) are involved in the brain metastasis of lung cancer cells. Thus, it is necessary to determine whether gap junction-forming Cxs are involved in the communication between lung cancer cells and the host cells, such as endothelial cells ...
Kai-Jun Luo +9 more
doaj +1 more source