Results 91 to 100 of about 5,094 (206)
Putative hemichannel currents were increased in the HeLa cells-expressing AF-linked Cx40 mutants.
, 2014 Voltage clamp ramp protocol (−40 to 110 mV) was used to study currents under divalent cation containing saline (DCC, black traces) and the divalent-cation free saline (DCF, red traces).
Xiaoling Tong (141534) +4 more
core +1 more source
Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca2+: Insight from a local quantum chemistry study [PDF]
, 2014 Connexin hemichannels are regulated by several gating mechanisms, some of which depend critically on the extracellular Ca2+ concentration ([Ca2+]e). It is well established that hemichannel activity is inhibited at normal (1 mM) [Ca2+]e, whereas lowering [
POLIMENO, ANTONINO +5 more
core +1 more source
Mechanism of gating by calcium in connexin hemichannels [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Connexin channels are ubiquitous, providing pathways for movement of molecules between cells (junctional channels) and for release of molecular effectors into the extracellular environment (plasma membrane hemichannels).
Lopez, William +5 more
openaire +4 more sources
Membrane‐Associated Biomolecules for Synthetic Cell Signalling
ChemBioChem, Volume 27, Issue 13, 14 July 2026.Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack +3 more
wiley +1 more source
, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Victoria Velarde (5632436) +10 more
core +1 more source
Stimulation of the A2B adenosine receptor subtype enhances connexin26 hemichannel activity in small airway epithelial cells [PDF]
, 2019 Background/Aims: Adenosine release and connexin (Cx) hemichannel activity are enhanced in the respiratory epithelium during pathophysiological events such as inflammation.
Dierks, Anne +3 more
core +1 more source
The Neuroglial Dialog Between Cannabinoids and Hemichannels [PDF]
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules during physiological and pathological conditions.
Valeria C. Labra +11 more
openaire +4 more sources
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. [PDF]
PLoS ONE, 2013 Connexin channels play a critical role in maintaining metabolic homeostasis and transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in humans.
Qian Ren +6 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source