Results 91 to 100 of about 9,855 (254)

Mind the gap: connexins and cell–cell communication in the diabetic kidney [PDF]

, 2015
Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells.
A Abed, A Awad, A Cove-Smith, A Kurtz, A Mendoza-Naranjo, A Pfenniger, A Sipos, AF Li, AF Li, BN Giepmans, C Qiu, C Wagner, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, Claire E. Hills, CM Wang, CS Wright, D Bosco, D Lu, DW Laird, E Yaoita, F Hanner, F Mumtaz, G Sahu, Gareth W. Price, GS Goldberg, GS Hillis, GS Hillis, I Loeffler, J Gilleron, J Kronengold, J Wada, J Yao, J Yao, J Yao, J Zhang, JA Haefliger, JA Haefliger, JA Wright, JC Herve, JH Zhang, K Fujimoto, K Sawai, L Gal Le, L Liu, M Dalla Vestra, M Firouzi, M Gerl, M Oppermann, M Oyamada, MA Retamal, MS Nielsen, MW Bobbie, N Defamie, N Krattinger, N Wang, P Svenningsen, Paul E. Squires, PD Lampe, Q Yan, R Hernández-Salinas, R Hirschberg, RM Mege, S Tsuchida, SP Prabhakar, SS Prabhakar, T Inoguchi, T Morioka, T Sato, T Takenaka, T Takenaka, T Tien, WM Jongen, X Xie, X Zhang, Y Liu, Y Suzaki, YC Lee   +82 more
core   +1 more source

Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis

Scientific Reports, 2019
We have recently reported an important role of Connexin 43 (Cx43) hemichannels in the pathogenesis of lethal sepsis through facilitating ATP efflux to potentiate the double-stranded RNA-activated protein kinase R (PKR)-dependent macrophage activation ...
Weiqiang Chen, Shu Zhu, Yongjun Wang, Jianhua Li, X. Qiang, Xiaoling Zhao, Huan Yang, J. D’Angelo, L. Becker, Ping Wang, K. Tracey, Haichao Wang   +11 more
semanticscholar   +1 more source

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death [PDF]

, 2018
Erythrokeratodermia variabilis et progressiva (EKV-P) is caused by mutations in either the GJB3 (Cx31) or GJB4 genes (Cx30.3). We identified a rare GJB3 missense mutation, c.134G>A (p.G45E), in two unrelated patients and investigated its cellular ...
Alboulshi, A. K., Broers, M. R., Brouns, G. H., Coull, Barry. J., Easton, J. A., Kamps, M. A. F., Martin, P. E., Oji, V., van Geel, M., van Steensel, M. A. M.   +9 more
core   +5 more sources

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between neighbouring cells.
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
openaire   +3 more sources

Connexin43 Hemichannel-Mediated Regulation of Connexin43

PLoS ONE, 2013
Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
openaire   +4 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov, Ganna V. Sotkis, Semen I. Yelyashov, Valeri G. Naidenov, Yaroslav M. Shuba   +4 more
wiley   +1 more source

The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation

Frontiers in Physiology, 2019
Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain injury is typically associated with hypoxia-ischemia and/or infection/inflammation.
Kelly Q. Zhou, Colin R. Green, Laura Bennet, Alistair J. Gunn, Joanne O. Davidson   +4 more
doaj   +1 more source