Results 91 to 100 of about 4,743 (216)

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

Frontiers in Neurology, 2020
Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino ...
Zhen Liang, Xu Wang, Yulei Hao, Lin Qiu, Yingyue Lou, Yaoting Zhang, Di Ma, Jiachun Feng   +7 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, Volume 4, Issue 2, June 2026.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between neighbouring cells.
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
openaire   +3 more sources

Molecular dynamics simulations highlight structural and functional alterations in deafness–related M34T mutation of connexin 26

Frontiers in Physiology, 2014
Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widelyexpressed in the inner ear, are the primary cause of hereditary non–syndromic hearing loss in severalpopulations.
Francesco eZonta, Damiano eBuratto, Chiara eCassini, Mario eBortolozzi, Mario eBortolozzi, Fabio eMammano, Fabio eMammano, Fabio eMammano   +7 more
doaj   +1 more source

Molecular Mechanisms Underlying Enhanced Hemichannel Function of a Cataract-associated Cx50 Mutant [PDF]

, 2021
Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. Although most of these disease-linked variants cause loss of function because of misfolding or aberrant trafficking, others directly alter channel ...
Minogue, Peter J., Ebihara, Lisa, Tong, Jun-Jie, Ebihra, Lisa, Beyer, Eric C., Reichow, Steve L., Khan, Umair, Berthoud, Vivian M., Haddad, Bassam G., Berthoud, Viviana M., Haddad, Bassam George   +10 more
core   +2 more sources

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Mechanism of gating by calcium in connexin hemichannels [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Connexin channels are ubiquitous, providing pathways for movement of molecules between cells (junctional channels) and for release of molecular effectors into the extracellular environment (plasma membrane hemichannels).
Lopez, William, Ramachandran, Jayalakshmi, Alsamarah, Abdelaziz, Luo, Yun, Harris, Andrew L, Contreras, Jorge E   +5 more
openaire   +4 more sources

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Frontiers in Cellular Neuroscience, 2018
Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is a constituent of gap junctions and hemichannels. In physiological states, gap junctions are open for regular intercellular communication, and the hemichannels ...
Yingzhu Chen, Yingzhu Chen, Liangzhu Wang, Liangzhu Wang, Lingling Zhang, Lingling Zhang, Beilei Chen, Beilei Chen, Liu Yang, Liu Yang, Xiaobo Li, Xiaobo Li, Xiaobo Li, Yuping Li, Yuping Li, Hailong Yu, Hailong Yu, Hailong Yu, Hailong Yu   +18 more
doaj   +1 more source

Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells [PDF]

, 2010
Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signalling. The functional integrity of the
Sue Lang, Jennifer Robertson, Martin, Patricia E.M., Patricia E. Martin, Martin, Patricia E, Lambert, Peter A, Peter A. Lambert, Lambert, Peter A., Robertson, Jennifer, Lang, Sue   +9 more
core   +1 more source

Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Daniela Enriquez‐Ochoa, Raji R. Nagalla, Yingzi Liu, Christian F. Guerrero‐Juarez, Hamza Atcha, Gordon Chang, Nancy A. Morales, Hannah J. Hooper, Arian D. Cano, Huy Eng Lim, Michael D. Cahalan, Maksim V. Plikus, Wendy F. Liu   +12 more
wiley   +1 more source