Results 81 to 90 of about 4,743 (216)
Pharmaceuticals, 2021 Accumulating neuropsychopharmacological evidence has suggested that functional abnormalities of astroglial transmission and protein kinase B (Akt) contribute to the pathophysiology and/or pathomechanisms of several neuropsychiatric disorders, such as ...
Kouji Fukuyama, Motohiro Okada
doaj +1 more source
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
Stimulation of the A2B adenosine receptor subtype enhances connexin26 hemichannel activity in small airway epithelial cells [PDF]
, 2019 Background/Aims: Adenosine release and connexin (Cx) hemichannel activity are enhanced in the respiratory epithelium during pathophysiological events such as inflammation.
Dierks, Anne +3 more
core +2 more sources
Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases [PDF]
, 2021 Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway ...
Colin R. Green +3 more
core +1 more source
Pharmaceuticals, 2020 To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular ...
Kouji Fukuyama +3 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
Modulation of Cx46 hemichannels by nitric oxide
American Journal of Physiology-Cell Physiology, 2009 Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A. +3 more
openaire +5 more sources
Connexins in Lung Cancer and Brain Metastasis
Frontiers in Oncology, 2020 Connexins (Cxs) are involved in the brain metastasis of lung cancer cells. Thus, it is necessary to determine whether gap junction-forming Cxs are involved in the communication between lung cancer cells and the host cells, such as endothelial cells ...
Kai-Jun Luo +9 more
doaj +1 more source
Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes
Advanced Science, Volume 13, Issue 33, 15 June 2026.Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan +8 more
wiley +1 more source
Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca2+: Insight from a local quantum chemistry study [PDF]
, 2014 Connexin hemichannels are regulated by several gating mechanisms, some of which depend critically on the extracellular Ca2+ concentration ([Ca2+]e). It is well established that hemichannel activity is inhibited at normal (1 mM) [Ca2+]e, whereas lowering [
POLIMENO, ANTONINO +5 more
core +1 more source