Results 1 to 10 of about 4,332 (134)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism [PDF]

Advanced Science
Ventricular arrhythmias (VAs) as life‐threatening heart rhythm disorders, reduced connexin43 (Cx43) is one of the mechanisms of VAs. Cx43 is the predominant ventricular gap junction protein essential for cardiac electrical conduction; the absence in the ...
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
doaj   +3 more sources

Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment

Biomolecules, 2020
In epilepsy research, emphasis is put on exploring non-neuronal targets such as astrocytic proteins, since many patients remain pharmacoresistant to current treatments, which almost all target neuronal mechanisms.
Mathieu Vinken, Luc Leybaert, Laura Walrave   +2 more
exaly   +3 more sources

Mechanisms of spinal glial activation in chemotherapy-induced peripheral neuropathy: Focus on microglia and astrocytes. [PDF]

Ibrain
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Gu L, Cao S, Feng Y.
europepmc   +2 more sources

Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology

Biology, 2022
For the first time in animal evolution, the emergence of gap junctions allowed direct exchanges of cellular substances for communication between two cells.
Yi Zhu
doaj   +1 more source

Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine‐Mediated Inhibition of Connexin43 Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury.
Pietro Enea Lazzerini, Maurizio Acampa, Michael Cupelli, Alessandra Gamberucci, Ujala Srivastava, Claudio Nanni, Iacopo Bertolozzi, Francesca Vanni, Alessandro Frosali, Anna Cantore, Alessandra Cartocci, Antonio D’Errico, Viola Salvini, Riccardo Accioli, Decoroso Verrengia, Fabio Salvadori, Aleksander Dokollari, Massimo Maccherini, Nabil El‐Sherif, Franco Laghi‐Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir   +21 more
doaj   +1 more source

Both PKA and Epac pathways mediate N-acetylcysteine-induced Connexin43 preservation in rats with myocardial infarction. [PDF]

PLoS ONE, 2013
Cardiac remodeling was shown to be associated with reduced gap junction expression after myocardial infarction. A reduction in gap junctional proteins between myocytes may trigger ventricular arrhythmia.
Tsung-Ming Lee, Shinn-Zong Lin, Nen-Chung Chang   +2 more
doaj   +1 more source

Connexin43 hemichannel-mediated regulation of connexin43. [PDF]

PLoS ONE, 2013
BACKGROUND: Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs.
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
doaj   +1 more source

Members of the AP-1 Family of Transcription Factors Regulate the Expression of Gja1 in Mouse GC-1 Spermatogonial Cells

Applied Sciences, 2022
Gap junctions, mainly formed by Gja1 (Connexin43), play an essential role in the regulation of proliferation and differentiation of spermatogonia in the testis.
Mustapha Najih, Audrey Basque, Ha Tuyen Nguyen, Mariama Diawara, Luc J. Martin   +4 more
doaj   +1 more source

Translating Translation to Mechanisms of Cardiac Hypertrophy

Journal of Cardiovascular Development and Disease, 2020
Cardiac hypertrophy in response to chronic pathological stress is a common feature occurring with many forms of heart disease. This pathological hypertrophic growth increases the risk for arrhythmias and subsequent heart failure.
Michael J. Zeitz, James W. Smyth
doaj   +1 more source

An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression

Biomolecules, 2020
Connexin 43 (Cx43) is a gap junction protein that assembles at the cell border to form intercellular gap junction (GJ) channels which allow for cell−cell communication by facilitating the rapid transmission of ions and other small molecules between
Irina Epifantseva, Shaohua Xiao, Rachel E. Baum, André G. Kléber, TingTing Hong, Robin M. Shaw   +5 more
doaj   +1 more source