Changes in gap junction proteins Connexin30.2 and Connexin40 expression in the sinoatrial node of rats with dexmedetomidine-induced sinus bradycardia [PDF]
Brazilian Journal of Anesthesiology, 2022 Background: Dexmedetomidine (Dex) is widely used, and its most common side effect is bradycardia. The complete mechanism through which Dex induces bradycardia has not been elucidated.
Yong-Qiang Yin +3 more
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Maintenance and Reversibility of Paroxysmal Atrial Fibrillation in JDP2 Overexpressing Mice [PDF]
CellsHeart-specific overexpression of transcriptional regulator JDP2 (jun dimerization protein 2) for 5 weeks provokes paroxysmal atrial fibrillation (AF) in mice.
Gerhild Euler +5 more
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Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective [PDF]
Frontiers in Physiology, 2020 The endothelium controls vascular tone adopting blood flow to tissue needs. It releases chemical mediators [e.g., nitric oxide (NO), prostaglandins (PG)] and exerts appreciable dilation through smooth muscle hyperpolarization, thus termed endothelium ...
Kjestine Schmidt +3 more
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Angiopoietin‐1 Promotes the Integrity of Neovascularization in the Subcutaneous Matrigel of Type 1 Diabetic Rats [PDF]
BioMed Research International, Volume 2019, Issue 1, 2019., 2019 Objective. This study aimed to investigate the effects of Ang‐1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods. Ang‐1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group.
ShaoBin LI +7 more
wiley +2 more sources
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation [PDF]
Journal of Translational MedicineBackground Atrial fibrillation (AF) is associated with increased risk of stroke and mortality. It has been reported that the process of atrial fibrosis was regulated by β-catenin in rats with AF.
Ying Bai +9 more
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Cardiac foetal reprogramming: a tool to exploit novel treatment targets for the failing heart [PDF]
Journal of Internal Medicine, Volume 288, Issue 5, Page 491-506, November 2020., 2020 Content List ‐ Read more articles from the symposium: “Cardiovascular program and cardiovascular retreat”. Abstract As the heart matures during embryogenesis from its foetal stages, several structural and functional modifications take place to form the adult heart.
A. van der Pol +3 more
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QUALITATIVE ASSESSMENT OF RENAL BLOOD PRESSURE USING NANOTECHNOLOGY INTERVENTION
Central Asian Journal of Medical Hypotheses and Ethics, 2023 The renal system is one of the major organ systems present in the human body, it is responsible for maintaining electrolyte balance, secreting important hormones, and maintaining homeostasis in the body.
Parth Shah +2 more
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The role of SARS‐CoV‐2 target ACE2 in cardiovascular diseases
Journal of Cellular and Molecular Medicine, Volume 25, Issue 3, Page 1342-1349, February 2021., 2021 Abstract SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to angiotensin‐converting enzyme 2 (ACE2) to enter cells. More than 20 million people have already been infected by the virus.
Hanzhao Zhu +7 more
wiley +1 more source
Frontiers in Pharmacology, 2013 Connexin43 (Cx43) is widely expressed in many different tissues of the human body. In cells of some organs, Cx43 is co-expressed with other connexins (Cx), including Cx46 and Cx50 in lens, Cx40 in atrium, Purkinje fibers, and the blood vessel wall, Cx45 ...
Richard David Veenstra +2 more
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The CAR group of Ig cell adhesion proteins–Regulators of gap junctions?
BioEssays, Volume 42, Issue 12, December 2020., 2020 CAR, CLMP, BT‐IgSF and ESAM form a small group of homophilic cell adhesion molecules within immunoglobulin superfamily. On the basis of genetic studies the author hypothesizes that these Ig‐like proteins primarily play a role in the organization of gap junction communication.
Fritz G. Rathjen
wiley +1 more source