Results 41 to 50 of about 760 (141)

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, Volume 13, Issue 23, 23 April 2026.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

A Connexin40 Mutation Associated With a Malignant Variant of Progressive Familial Heart Block Type I [PDF]

, 2012
Background-Progressive familial heart block type I (PFHBI) is a hereditary arrhythmia characterized by progressive conduction disturbances in the His-Purkinje system.
Mochizuki, Naoki, Baruteau, Alban, Wilde, Arthur A.M., Hagiwara, Nobuhisa, Le Marec, Hervé, Shimizu, Wataru, Hasdemir, Can, Horie, Minoru, Wilde, Arthur A. M., Makita, Naomasa, Probst, Vincent, Bezzina, Connie R., Makiyama, Takeru, Baron, Estelle, Delmar, Mario, Schott, Jean-Jacques, Roden, Dan M., Sumitomo, Naokata, Seki, Akiko, Fukuhara, Shigetomo, Mugishima, Hideo, Chkourko, Halina, Le, Marec Hervé, Watanabe, Hiroshi   +23 more
core   +1 more source

Expression of Connexin-40 and Interleukin 6 Genes in Patients with Atrial Fibrillation

Acta Clinica Croatica
Atrial fibrillation (AF) is the outcome of the rapid onset of abnormal electrical impulses in the atria. These impulses prevent the heart natural pacemaker, which normally controls the heart beat, from doing its job.
Saima Sharif, Hafsa Ijaz, Saira Rafaqat, Shabina Waris, Shagufta Naz, Aleksandra Klisic   +5 more
doaj   +1 more source

Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives

IUBMB Life, Volume 76, Issue 11, Page 862-882, November 2024.
Abstract Ginsenosides are the primary component discernible from ginseng, including Rb1, Rb2, Rd, Rg1, Rg2, and compound K, and so forth. They have been shown to have multiple pharmacological activities. In recent years, more and more studies have been devoted to the neuroprotection of various ginsenosides against neurological diseases and their ...
Li Zhou, Feilong Tan, Xue Zhang, Yanhua Li, Wenjie Yin   +4 more
wiley   +1 more source

Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations

, 2016
International audienceOBJECTIVE:To determine the role of Gja5 that encodes for the gap junction protein connexin40 in the generation of arteriovenous malformations in the hereditary hemorrhagic telangiectasia type 2 (HHT2) mouse model.APPROACH AND ...
Gkatzis, K., Mager, J.J., Thalgott, J., Dos-Santos-Luis, D., Oh, S.P., Martin, S., Mummery, C.L., Arthur, H.M., Snijder, R.J., Lamandé, N., Carette, M.F., Westermann, C.J., Miquerol, L., Disch, F., Lebrin, F.   +14 more
core   +1 more source

Aging‐associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms

Aging Cell, Volume 23, Issue 10, October 2024.
Our review highlights the potential mechanisms of aging‐associated atrial fibrillation, and in particular describes the potential relationship between new aging features and aging‐associated atrial fibrillation, including mitochondrial dysfunction, telomere attrition, cellular senescence, macroautophagy dysfunction, and gut dysbiosis, to deepen our ...
Meng‐Fei Wang, Can Hou, Fang Jia, Cheng‐Hao Zhong, Cong Xue, Jian‐Jun Li   +5 more
wiley   +1 more source

The role of connexin40 in atrial fibrillation

, 2009
Connexin40 (Cx40) is a major gap-junction protein in the atrial myocardium. In the heart, gap junctions are responsible for cell-to-cell conduction of the action potential.
Harold V. M. Van Rijen, Hauer, Richard N. W., van Rijen, Harold V. M., Sevasti-maria Chaldoupi, Chaldoupi, Sevasti-Maria, Peter Loh, de Bakker, Jacques M. T., Loh, Peter, Jacques M. T. De Bakker, Richard N. W. Hauer   +9 more
core   +1 more source

Role of Gap Junction in Atrial Fibrillation Pathophysiology

Majalah Kardiologi Indonesia, 2013
Initiation of atrial fibrillation (AF) occurred when there is a combination of triggering factors (mainly originated from thoracic veins) and arrhytmogenic substrate, such as : reduction of effective refractory period (ERP), increase in refractory ...
doaj   +1 more source

Development of ventricular trabeculae affects electrical conduction in the early endothermic heart

Developmental Dynamics, Volume 253, Issue 1, Page 78-90, January 2024.
Key Findings A methodology for creating chick trabeculae‐deficient heart. Trabeculae allow preferential electrical conduction inside of the early endothermic heart. Depletion of trabecular networks results in persistence of slow and isotropic electrical conduction with consequent embryonic heart failure.
Veronika Olejnickova, Peter Uriel Hamor, Jiri Janacek, Martin Bartos, Eva Zabrodska, Barbora Sankova, Alena Kvasilova, Hana Kolesova, David Sedmera   +8 more
wiley   +1 more source

Ionic Blockade of the Rat Connexin40 Gap Junction Channel by Large Tetraalkylammonium Ions [PDF]

, 2001
The rat connexin40 gap junction channel is permeable to monovalent cations including tetramethylammonium and tetraethylammonium ions. Larger tetraalkyammonium (TAA+) ions beginning with tetrabutylammonium (TBA+) reduced KCl junctional currents ...
Hassan Musa, Jonathan D. Gough, Lees, Watson J., Watson J. Lees, Veenstra, Richard D., Musa, Hassan, Gough, Jonathan D., Richard D. Veenstra   +7 more
core   +1 more source