Results 21 to 30 of about 760 (141)

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker. [PDF]

PLoS ONE, 2015
Establishment of a biological pacemaker is expected to solve the persisting problems of a mechanical pacemaker including the problems of battery life and electromagnetic interference.
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F Kusano, Hiroshi Ito   +11 more
doaj   +1 more source

Gap-junctional coupling between neutrophils and endothelial cells [PDF]

, 2003
Communication between leukocytes and endothelial cells is crucial for inflammatory reactions. Paracrine cross-talk and outside-in signaling (via adhesion molecules) have been characterized as communication pathways to date.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Connexin40 regulates renin production and blood pressure [PDF]

, 2007
Renin secretion is regulated by coordinated signaling between the various cells of the juxtaglomerular apparatus. The renin-secreting cells (RSC), which play a major role in the control of blood pressure, are coupled to each other and to endothelial ...
Haefliger, J.-A., Haefliger, J.A., Nicod, P., Aubert, J.-F., Mazzolai, L., Meda, P., Aubert, J.F., Krattinger, N., Capponi, A., Caille, D., Waeber, G.   +10 more
core   +1 more source

Regulation of Connexin40 Gap Junctions [PDF]

, 2007
Gap junctions provide direct electrical and biochemical communication between cardiomyocytes in the heart. Connexin40 (Cx40) is the major connexin in the atria of the heart and little is known regarding its regulation.
Sheela, Thomas Vinaya
core   +1 more source

Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]

, 2003
Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

SIRT1 and Connexin40 Mediate the Normal Shear Stress-Induced Inhibition of the Proliferation of Endothelial Cells Co-Cultured with Vascular Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2013
Background: Shear stress imposed by blood flow directly impacts endothelial cells (ECs), which are simultaneously influenced by neighboring vascular smooth muscle cells (VSMCs).
Qing-Ping Yao, Ying-Xin Qi, Ping Zhang, Bin-Bin Cheng, Zhi-Qiang Yan, Zong-Lai Jiang   +5 more
doaj   +1 more source

Low prevalence of connexin-40 gene variants in atrial tissues and blood from atrial fibrillation subjects

BMC Medical Genetics, 2012
Background The atrial gap junction protein connexin-40 (Cx40) has been implicated to play an important role in atrial conduction and development of atrial fibrillation (AF).
Tchou Gregory D, Wirka Robert C, Van Wagoner David R, Barnard John, Chung Mina K, Smith Jonathan D   +5 more
doaj   +1 more source

Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes.

PLoS ONE, 2013
The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function.
Montserrat Barriga, Roi Cal, Nuria Cabello, Anna Llach, Alexander Vallmitjana, Raúl Benítez, Lina Badimon, Juan Cinca, Vicenta Llorente-Cortés, Leif Hove-Madsen   +9 more
doaj   +1 more source

Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells [PDF]

, 1994
Human HeLa or SkHep1 cells, defective in intercellular communication through gap junctions, were transfected with coding sequences of murine connexin40 (Cx40) and -43.
Bastide, Bruno, Elfgang, Claudia, Traub, Otto, Willecke, Klaus, Hülser, Dieter F., Lichtenberg-Fraté, Hella, Scheidtmann, Karl Heinz, Eckert, Reiner   +7 more
core   +1 more source

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto‐Kakizaki Type 2 Diabetic Rat Heart

Journal of Diabetes Research, Volume 2018, Issue 1, 2018., 2018
Background. In vivo experiments in Goto‐Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated to further clarify the molecular ...
F. C. Howarth, M. A. Qureshi, P. Jayaprakash, K. Parekh, M. Oz, H. Dobrzynski, T. E. Adrian, Michaelangela Barbieri   +7 more
wiley   +1 more source